기본 정보
- CAS
132-73-0- 표준 SMILES
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12.O=S(=O)(O)O- InChIKey
OJPWHUOVKVKBQB-UHFFFAOYSA-N- 분자식
- C18H28ClN3O4S
- 평균 분자량
- 418 g/mol
- 단동위원소 질량
- 417.1489053
개요
Chloroquine Sulfate is the sulfate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids.
이름 및 식별자
- 우선 이름
- Chloroquine Sulfate
- IUPAC
- 4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine;sulfuric acid
- 현지명
- 황산클로로퀸
- 영어명
- Chloroquine sulfate
- 분자식
- C18H28ClN3O4S
- 분자량
- 417.95
이름 및 동의어
Chloroquine sulfate132-73-0Chloroquine sulphateLariagoNivaquineCisplaquinMelubrinChlorquine sulfateChloroquin sulfateNSC-292296CIPLAQUINMELUBRINE
이름 더 보기
황산클로로퀸chloroquinsulfateCHLOROQUINESULPHATEChloroquine sulfate CRSChloroquine sulfate saltKOQRRSSOQDJMID-UHFFFAOYSA-NChloroquine Sulfate (500 mg)
OE48649K6N7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline sulfate (1:1)NSC292296CHEBI:50178RefChem:125507205-077-61,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, sulfate (1:1)N4-(7-chloroquinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine sulfate
데이터베이스 식별자
- CAS
132-73-0- PubChem CID
- 91441
- ChEMBL
CHEMBL2095223- UNII
- OE48649K6N
- EC Number
- 205-077-6
물성
구조 계산 물성
- 극성 표면적
- 111 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 8
- 무거운 원자 수
- 27
- 형식 전하
- 0
- 복잡도
- 390
실험 및 물리화학적 성질
Human DrugsBreast Feeding; Lactation; Milk, Human; Anti-infective Agents; Antiparasitic Agents; Antimalarials; Antirheumatic Agents; Antiprotozoal Agents
물리화학적 성질
- 녹는점
- 204 °C · >204°C (dec.)
- 저장 조건
- Refrigerator, under inert atmosphere
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨), 물(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 흰색에서 황백색까지
- BCS Class
- 1 · 1
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P319, P330, P337+P317, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
유해성 정보
Other Safety InformationIMAP assessments - 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, sulfate (1:1): Human health tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
독성 정보
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
안전 데이터
- ridadr
- 1544
- 독성
- women,TDLo,oral,120mg/kg (120mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYECARDIAC: CARDIOMYOPATHY INCLUDING INFARCTIONBEHAVIORAL: COMA,Journal of Toxicology, Clinical Toxicology. Vol. 29, Pg. 23, 1991.
- 포장분류
- III
- 위험 등급
- 6.1(b)
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.
Agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human. (From AMA, Drug Evaluations Annual, 1992, p1585)
Drugs that are used to treat RHEUMATOID ARTHRITIS.
응용 분야
용도Chloroquine Sulfate is a Chloroquine salt, used in the treatment of malaria and MDR-strains. It is a COVID19-related research product.
공급사37 곳
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
深圳市健竹科技有限公司0755-89218110 13480856786 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
卓瑞宁（上海）科技有限公司18163338995 18163338995 · [email protected]
江苏艾康生物医药研发有限公司025-5885952 15955137747 · [email protected]
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