펜플루라민염산염

Fenfluramine Hydrochloride

HCID 91452CAS 16105-77-4
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기본 정보

표준 SMILES
CCNC(C)Cc1cccc(C(F)(F)F)c1.Cl
InChIKey
ZXKXJHAOUFHNAS-UHFFFAOYSA-N
분자식
C12H17ClF3N
평균 분자량
267.72 g/mol
단동위원소 질량
267.10016188

개요

Fenfluramine Hydrochloride is the hydrochloride salt of fenfluramine, an amphetamine derivative and a sympathomimetic stimulant with appetite-suppressant properties. Fenfluramine, which was part of the Fen-Phen anti-obesity medication, stimulates the release of serotonin from vesicular storage, and modulates serotonin transporter function. Since serotonin regulates mood and appetite, among other functions, increased serotonin level results in a feeling of fullness and loss of appetite.

이름 및 식별자

우선 이름
Fenfluramine Hydrochloride
IUPAC
N-ethyl-1-[3-(trifluoromethyl)phenyl]propan-2-amine;hydrochloride
현지명
펜플루라민염산염
영어명
Fenfluramine hydrochloride
분자식
C12H17ClF3N
분자량
267.72

이름 및 동의어

Fenfluramine hydrochlorideFenfluramine HClGanal404-82-0PondiminPonderax pacapsAHR-3002HHR-9651-(3-Trifluoromethylphenyl)-2-ethylaminopropane hydrochloride3KC089243PN-Ethyl-alpha-methyl-m-(trifluoromethyl)phenethylamine hydrochlorideDTXSID30936444
이름 더 보기
펜플루라민염산염(+-)-fenfluraminechlorideFEBFLURAMINE HYDROCHLORIDEZXKXJHAOUFHNAS-UHFFFAOYSA-Ndl-fenfluraminehydrochlorideracemicfenfluraminehydrochloride(±)-Fenfluramine hydrochloride solution(±)-Fenfluramine solution hydrochloridefenfluramine hydrochloride*methanol solutionFENFLURAMINE HYDROCHLORIDE--DEA*SCHEDULE IV ITEM
Benzeneethanamine, N-ethyl-alpha-methyl-3-(trifluoromethyl)-, hydrochlorideCHEBI:59729RefChem:56386DTXCID901365052206-968-2dl-Fenfluramine hydrochloride16105-77-4Racemic fenfluramine hydrochloride

데이터베이스 식별자

CAS
16105-77-4、404-82-0
PubChem CID
91452
DTXSID
DTXSID30936444
ChEMBL
CHEMBL2106217
UNII
3KC089243P
EC Number
206-968-2、623-877-7

물성

구조 계산 물성

극성 표면적
12 Ų
수소 결합 공여자 수
2
수소 결합 수용자 수
4
회전 가능 결합 수
4
무거운 원자 수
17

실험 및 물리화학적 성질

Human Drugs · 3건

FDA approved drugs -> Active ingredient

EMA approved medicines: Human medicine (Orphan designations)

FDA approved drugs -> Active ingredient

물리화학적 성질

녹는점
166 C · 166 C
인화점
11 °C · 11 °C
저장 조건
2 · 2-8°C

안전 및 규제

GHS 분류

GHS Classification · 6건

Danger

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 2 notifications to the ECHA C&L Inventory.

Danger

H300 (50%): Fatal if swallowed [Danger Acute toxicity, oral]

유해성 정보

Regulatory InformationBenzeneethanamine, N-ethyl-.alpha.-methyl-3-(trifluoromethyl)-, hydrochloride: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - Benzeneethanamine, N-ethyl-.alpha.-methyl-3-(trifluoromethyl)-, hydrochloride: Human health tier I assessment
Hazard Classes and Categories · 2건

Acute Tox. 2 (50%)

Acute Tox. 3 (100%)

안전 데이터

wgk
3
rtecs
DA0295500
ridadr
UN 2811 6.1/PG 3
risk_code
25-39/23/24/25-23/24/25-11-36/37/38
hazard_code
T,F,Xi
safety_code
7-16-36/37-45-28-22-36-26

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 2건

Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.

Compounds that specifically inhibit the reuptake of serotonin in the brain.

공급사3 곳

杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
Zhejiang J&C Biological Technology Co.,Limited+1-2135480471 · [email protected]
Alchem Pharmtech,Inc.8485655694 · [email protected]

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