Hydroxyzine Hydrochloride

Danger

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]；H314 (11.9%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]；H315 (59.7%): Causes skin irritation [Warning Skin corrosion/irritation]；H317 (23.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]；H319 (59.7%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (61.2%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]；H360 (23.9%): May damage fertility or the unborn child [Danger Reproductive toxicity]

P203, P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 67 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Status: Active Update: 21-12-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/33066

Ethanol, 2-2-4-(4-chlorophenyl)phenylmethyl-1-piperazinylethoxy-, dihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

IMAP assessments - Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride: Environment tier I assessment；IMAP assessments - Ethanol, 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-, dihydrochloride: Human health tier I assessment

Drug Induced Liver Injury Rank (DILIrank 2.0)

Hydroxyzine hydrochloride

vNo-DILI-concern

0

No match

DOI:10.1016/j.drudis.2016.02.015

Status: Active Update: 21-12-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/33066

Ethanol, 2-2-4-(4-chlorophenyl)phenylmethyl-1-piperazinylethoxy-, dihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

HYDROXYZINE HCL

Antihistamine [EPC]; Histamine Receptor Antagonists [MoA]

HYDROXYZINE HYDROCHLORIDE

Histamine Receptor Antagonists [MoA]; Antihistamine [EPC]

Agents, usually topical, that relieve itching (pruritus).

Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.