기본 정보
- CAS
8047-67-4- 표준 SMILES
O.O.O.OC[C@H]1O[C@@](CO)(O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O)[C@@H]1O.[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Fe+3].[Na+].[Na+].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[OH-]- InChIKey
ADQSUDSYBZBMFT-JMMWHMDLNA-H- 분자식
- C12H29Fe5Na2O23
- 평균 분자량
- 866.5 g/mol
- 단동위원소 질량
- 866.76418
개요
Iron sucrose (sucroferric oxyhydroxide or iron saccharate) is used as a source of iron in patients with iron deficiency anemia with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis. Due to less side effects than iron dextran, iron sucrose is more preferred in chronic kidney disease patients.
이름 및 식별자
- 우선 이름
- Succharated ferric oxide
- IUPAC
- disodium;(2R,3R,4S,5S,6R)-2-[(2S,3S,4S,5R)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;pentakis(iron(3+));octakis(oxygen(2-));hydroxide;trihydrate
- 영어명
- Iron saccharate
- 분자식
- C18H24Fe2O24
- 분자량
- 736.06
이름 및 동의어
Succharated ferric oxideRefChem:1099121Sucroferric oxyhydroxideFerriveninFeojectinVenoferrumEnciferFerijetHippironProferrinSucroferVelphoro
이름 더 보기
VenoferIronSucroseIron sucrose liquidIRON (III) OXIDE, SACCHARATEDXI 921
IvironFesinFerum HausmannFerrum VitisNeo-ferrumFerosoft SFe-backFerplex SS
데이터베이스 식별자
- CAS
8047-67-4- PubChem CID
- 91663255
물성
구조 계산 물성
- 극성 표면적
- 202 Ų
- 수소 결합 공여자 수
- 12
- 수소 결합 수용자 수
- 23
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 42
- 형식 전하
- 0
- 복잡도
- 395
실험 및 물리화학적 성질
Human Drugs
Breast Feeding; Lactation; Milk, Human; Ferric Compounds; Hematinics; Iron Compounds
Breast Feeding; Lactation; Milk, Human; Ferric Compounds; Iron Compounds
EMA approved medicines: Human medicine
물리화학적 성질
- 녹는점
- 168 · 168-171°C
- 저장 조건
- Refrigerator
- 용해도
- 물(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 갈색에서 진한 갈색까지
- InChI
- InChI=1/3C6H10O8.2Fe/c3*7-1(3(9)5(11)12)2(8)4(10)6(13)14;;/h3*1-4,7-10H,(H,11,12)(H,13,14);;/q;;;2*+3/p-6/t3*1-,2-,3-,4+;;/s3
- InChIKey
- ADQSUDSYBZBMFT-JMMWHMDLNA-H
- EPA
- Iron saccharate (8047-67-4)
화학적 성질
Brown solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
독성 정보
Effects During Pregnancy and Lactation
◉ Summary of Use during Lactation
◉ Summary of Use during Lactation
안전 데이터
- 독성
- LD50 in mice (mg Fe/kg): >2500 orally; >200 i.v. (Geisser)
- HS 번호
- 29400090
화학 및 산업
약리 정보
ATC Code
V - Various
QV - Various
Protein BindingIt binds with transferrin.
PharmacodynamicsSignificant increases in serum iron and serum ferritin and significant decreases in total iron binding capacity occurred four weeks from the initiation of iron sucrose treatment.
Mechanism of Action
Following intravenous administration, iron sucrose is dissociated into iron and sucrose and the iron is transported as a complex with transferrin to target cells including erythroid precursor cells. The iron is then incorporated into hemoglobin as the cells mature into red blood cells.
Biological Half-Life6 hours.
Metabolism/MetabolitesFollowing IV administration, dissociated into iron and sucrose by the reticuloendothelial system.
FDA Pharmacological Classification
SUCROFERRIC OXYHYDROXIDE
Phosphate Binder [EPC]; Phosphate Chelating Activity [MoA]
Absorption, Distribution and Excretion
The intravensously administered iron sucrose injection would result rapidly in high serum iron levels. Maximum measured levels occured after 10 min of injection with an average of 30.00 mg/l.
Renal elimination of iron contributed very little to the total elimination (in average less than 5%). While, renal elimination of sucrose accounts for 68-75% of the administered dose after 4 and 24 hours respectively.
Vd is 7.3 L
Total body clearance is 20.5 ml/min.
용도 및 제조
Household ProductsInformation on 2 consumer products that contain Succharated ferric oxide in the following categories is provided:
응용 분야
용도Iron Saccharate has been used to treat iron deficiency and iron deficiency anemia associated with different chronic diseases.
공급사100 곳
北京华美互利生物化工010-56205725 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
爱斯特（成都）生物制药股份有限公司+86-28-85122536 85324413 · [email protected]
Baoji Guokang Healthchem co.,ltd+8615604608665 15604608665 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
上海弘顺生物科技有限公司15901914505 · [email protected]
Jai Radhe Sales+(91)-(79)-26431096/65255722 · [email protected]
江西瑞威尔生物科技有限公司400-880-2824 18107960669 · [email protected]
河北秒变生物科技有限公司17733850068
上海晶抗生物工程有限公司021-54721350 13524668266 · [email protected]
太原市瑞和丰科贸有限公司+86 351 7031519 · [email protected]
上海德默医药科技有限公司400-021-7337 2355568890 · [email protected]
博瑞生物医药（苏州）股份有限公司0512-0512-62551764 18013103761 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
上海萃森医药科技有限公司13472757003 17721485422 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
上海泰坦科技股份有限公司4006009262 13023226327 · [email protected]
湖北广奥生物科技有限公司027-02702759223056 18162699093 · [email protected]
上海药坦药物研究开发有限公司15512780135 · [email protected]
武汉丰泰威远科技有限公司+86-27-8746-5837 +86-18627785180 · [email protected]
武汉丰泰威远科技有限公司027-87465837 19945049750 · [email protected]
安徽海康药业有限责任公司86-0556-5800026 17709662922 · [email protected]
江苏汇鸿国际集团医药保健品进出口有限公司025-84691373 15312418043 · [email protected]
山东西亚化学有限公司13355009207 13355009207 · [email protected]
Xiamen AmoyChem Co., Ltd+86-86-5926051114 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
上海遐瑞医药科技有限公司+86 21 61551611
南京生利德生物科技有限公司025-57798810 18652991625 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18602735115 · [email protected]
Xunteng International Trading Co.,Limited—
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
杭州大海生物医药有限公司63811159 18906514933 · [email protected]
杭州杰恒化工有限公司0571-87396432 · [email protected]
上海永叶生物科技有限公司86-021-61559134 15921386130 · [email protected]
凯试（上海）科技有限公司021-50135380 · [email protected]
湖北巨胜科技有限公司027-59599241 18871490274 · [email protected]
池州凯隆进出口贸易有限公司[email protected]
长沙晶康新材料科技有限公司0731-85118349 18874718518 · [email protected]
桦特昇生物科技（武汉）有限公司027-59207879 1972026995 18140587686 · [email protected]
TargetMol中国（陶术生物）021-021-33632979 15002134094 · [email protected]
Alfa Chemistry1-516-6625404 · [email protected]
BOC Sciences16314854226 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
芜湖诺威化学技术有限公司0553-8233716 18055326116 · [email protected]
资川生化科技(苏州)有限公司0512-66317708 13372112871 · [email protected]
杭州鼎燕化工有限公司0571-87157530-8003 18049756717 · [email protected]
武汉鑫儒化工有限公司15927387915 15337108568 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
Alfa Chemistry+1-5166625404 · [email protected]
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