기본 정보
- CAS
1235-82-1- 표준 SMILES
Cl.OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2- InChIKey
RDNLAULGBSQZMP-UHFFFAOYSA-N- 분자식
- C21H30ClNO
- 평균 분자량
- 347.9 g/mol
- 단동위원소 질량
- 347.2015923
개요
See also: Biperiden (has active moiety); Carapichea ipecacuanha (annotation moved to).
이름 및 식별자
- 우선 이름
- Biperiden Hydrochloride
- IUPAC
- 1-(2-bicyclo[2.2.1]hept-5-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol;hydrochloride
- 현지명
- 비페리덴염산염
- 영어명
- Biperiden hydrochloride
- 분자식
- C21H30ClNO
- 분자량
- 347.92
이름 및 동의어
Biperiden hydrochloride1235-82-1Biperiden HClAkinophylTasmolinBiperideni hydrochloridumDTXSID2047856Akineton retK35N76CUHFNSC-84989NSC-1709501-Bicycloheptenyl-1-phenyl-3-piperidinopropanol-1 hydrochloride
이름 더 보기
비페리덴염산염BIPERIDINE HCLBicamolAkiridenNSC 84989NSC 170950Biperidene HCLBiperideni ImpurityNSC 170950NSC 84989akinetonhydrochloride
DTXCID20278321-(bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochlorideCHEBI:591711-(bicyclo(2.2.1)hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochlorideRefChem:575271-(Bicyclo(2.2.1)hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol monohydrochloride214-976-2Akineton
데이터베이스 식별자
- CAS
1235-82-1- PubChem CID
- 92151
물성
구조 계산 물성
- 극성 표면적
- 23.5 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 24
- 형식 전하
- 0
- 복잡도
- 422
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 238 ° · 238°
- 저장 조건
- 2 · 2-8°C
- 용해도
- 20 mg/mL · DMSO: >20mg/mL
- 물리적 상태
- 가루
- 색상
- 회백색
- BCS Class
- 3 · 3/1
- 주요 응용
- 의약품(소분자)
- InChI
- InChI=1/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H/t17-,18+,20,21;/s3
- InChIKey
- RDNLAULGBSQZMP-PHPHQDSFNA-N
- SMILES
- C1(C[C@]2([H])C=C[C@@]1([H])C2)C(O)(CCN1CCCCC1)C1C=CC=CC=1.Cl |&1:2,6,r|
- NIST
- Akineton, hydrochloride(1235-82-1)
화학적 성질
White Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H228 (66.9%): Flammable solid [Danger Flammable solids]
P210, P240, P241, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P304+P340, P305+P351+P338, P317, P330, P337+P317, P370+P378, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 157 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesFlam. Sol. 1 (66.9%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Biperiden hydrochloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
안전 데이터
- wgk
- 3
- rtecs
- TN3706000
- 독성
- LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna)
- risk_code
- 22-R22
- hazard_code
- Xn
- Hazard Classifications
- Acute Tox. 4 Oral
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents used in the treatment of Parkinson's disease. The most commonly used drugs act on the dopaminergic system in the striatum and basal ganglia or are centrally acting muscarinic antagonists.
Agents that inhibit the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the MUSCARINIC ANTAGONISTS.
Drugs that bind to but do not activate MUSCARINIC RECEPTORS, thereby blocking the actions of endogenous ACETYLCHOLINE or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system.
응용 분야
용도Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.
일반 설명Biperiden hydrochloride,α-5-norbornen-2-yl- -phenyl-1-piperidinepropanolhydrochloride (Akineton hydrochloride), is a white, opticallyinactive, crystalline, odorless powder that is slightlysoluble in water, ether, alcohol, and chloroform and sparinglysoluble in methanol.
상·하류 제품 정보
상류 원료
공급사
관련 반응
0건
현재 필터 조건에 해당하는 반응 기록이 없습니다.
화합물 노트
불러오는 중…