CAS 4965-09-7 1-Methyl-1,2,3,4-tetrahydroisoquinoline (HCID 92214)

개요

1-methyl-1,2,3,4-tetrahydroisoquinoline is a member of isoquinolines.

이름 및 식별자

우선 이름: 1-Methyl-1,2,3,4-tetrahydroisoquinoline
IUPAC: 1-methyl-1,2,3,4-tetrahydroisoquinoline
영어명: 1-methyl-1,2,3,4-tetrahydroisoquinoline
분자식: C10H13N
분자량: 147.22

이름 및 동의어

1-Methyl-1,2,3,4-tetrahydroisoquinoline4965-09-71-M-ThiqIsoquinoline, 1,2,3,4-tetrahydro-1-methyl-DTXSID70897161B8PA6UPV68RefChem:76188DTXCID20837294803-804-7N-Methyl-1,2,3,4-tetrahydroisoquinolineMFCD007989891-Methyl-1,2,3,4-tetrahydro-isoquinoline

이름 더 보기

1MeTIQ1Methyltetrahydroisoquinoline1-Methyl-2,3,4-tetrahydroisoquinoline1-Methyl-1,2,3,4-tetrahydroisoquinoline,95%4965-09-7 (1-METHYL-1,2,3,4-TETRAHYDROISOQUINOLINE)

CHEMBL95456SCHEMBL327738CHEBI:125372CS-W002686AC-82711,2,3,4-Tetrahydro-1-methylisoquinoline(R)-1-Methyl-1,2,3,4-tetrahydro-isoquinoline(s)-1-methyl-1,2,3,4-tetrahydro-isoquinoline

데이터베이스 식별자

CAS: 4965-09-7
PubChem CID: 92214
DTXSID: DTXSID70897161
ChEMBL: CHEMBL95456
ChEBI: CHEBI:125372
UNII: B8PA6UPV68
EC Number: 803-804-7
Nikkaji: J103.205D

물성

구조 계산 물성

XLogP: 1.7
극성 표면적: 12 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 1
회전 가능 결합 수: 0
무거운 원자 수: 11
형식 전하: 0
복잡도: 133

물리화학적 성질

끓는 점: 119 ℃/18mm · 119℃/18mm
밀도: 0.966 · 0.966±0.06 g/cm3(Predicted)
굴절률: 1.557 to · 1.5570 to 1.5610
저장 조건: 2 · Keep in dark place,Inert atmosphere,2-8°C
물리적 상태: 액체
산도 계수 (pKa): 9.73 · 9.73±0.40(Predicted)
색상: 옅은 노랑
수용성: 물에 약간 용해됩니다.

화학적 성질

Colorless to pale yellow liquid

안전 및 규제

GHS 분류

GHS Classification · 4건

Warning

H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazard Classes and CategoriesAcute Tox. 4 (97.6%)

안전 데이터

HS 번호: 2933499090

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 1건

Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.

응용 분야 · 1건

용도1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) is an endogenous antidepressant and parkinsonism-preventing substance that demonstrates neuroprotectiveactivity. Following systemic administration in rats, 1-Methyl-1,2,3,4-tetrahydroisoquinoline produces antidepressant-like effect similar to the effect of imipramine. 1MeTIQ is a reversible short-acting moderate inhibitor of MAO A/B. Also known as 1,2,3,4-Tetrahydro-1-methylisoquinoline, 1MeTIQ. It is an important raw material and intermediate for revaprazan and pharmaceutical.