기본 정보
- CAS
1104-22-9- 표준 SMILES
Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1.Cl- InChIKey
GJNMJOHYRWHJQB-UHFFFAOYSA-N- 분자식
- C25H28Cl2N2
- 평균 분자량
- 427.4 g/mol
- 단동위원소 질량
- 426.1629543
개요
See also: Meclizine (has active moiety).
이름 및 식별자
- 우선 이름
- Meclizine Monohydrochloride
- IUPAC
- 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrochloride
- 영어명
- Meclizine dihydrochloride
- 분자식
- C25H29Cl3N2
- 분자량
- 463.87
이름 및 동의어
Meclizine MonohydrochlorideMeclozine hydrochlorideMeclozine monohydrochlorideMeclizine monohydrochloride anhydrous410538-37-3008PUV3986Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, hydrochloride (1:1)Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, monohydrochlorideANHYDROUS MECLOZINE HYDROCHLORIDERefChem:925416Duremesinmeclizine diHCl
이름 더 보기
Meclozine HcldiadrilbonamineNSC 28728Navidoxine)-4-(3-methyLMeclizine 2HClMeclozine ,Bonamineancolandihydrochloride
36236-67-6UNII-008PUV3986MLS000028709CHEMBL1085765SMR0000587361-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;hydrochloridePostafene dihydrochloride1-((4-Chlorophenyl)benzyl)-4-((m-tolyl)methyl)piperazine hydrochloride
데이터베이스 식별자
물성
구조 계산 물성
- 극성 표면적
- 6.5 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 5
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 447
물리화학적 성질
- 녹는점
- 210 to · 210.0 to 214.0 °C
- 저장 조건
- 2 · 2-8°C
- 용해도
- 5 mg/mL, · DMSO: 용해성5mg/mL, 투명(가온)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- InChI
- 1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H
- InChIKey
- VCTHNOIYJIXQLV-UHFFFAOYSA-N
- SMILES
- [Cl-].[Cl-].Clc1ccc(cc1)C(N3CCN(CC3)Cc4cc(ccc4)C)c2ccccc2.[H+].[H+]
- EPA
- 1 · Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, dihydrochloride (1104-22-9)
화학적 성질
White or yellowish-white, slightly hygroscopic, crystalline powder.
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
안전 데이터
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- TL2005000
- 독성
- LD50 oral in mouse: 1600mg/kg
- HS 번호
- 2933.59.8000
- risk_code
- 22-63
- hazard_code
- Xn
- safety_code
- 22-36
- Hazard Classifications
- Acute Tox. 4 OralRepr. 2
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Drugs used to prevent NAUSEA or VOMITING.
Drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. Included here are the classical antihistaminics that antagonize or prevent the action of histamine mainly in immediate hypersensitivity. They act in the bronchi, capillaries, and some other smooth muscles, and are used to prevent or allay motion sickness, seasonal rhinitis, and allergic dermatitis and to induce somnolence. The effects of blocking central nervous system H1 receptors are not as well understood.
Drugs that bind to but do not activate CHOLINERGIC RECEPTORS, thereby blocking the actions of ACETYLCHOLINE or cholinergic agonists.
Agents that are used to treat allergic reactions. Most of these drugs act by preventing the release of inflammatory mediators or inhibiting the actions of released mediators on their target cells. (From AMA Drug Evaluations Annual, 1994, p475)
응용 분야
개요Meclizine is a histamine H1 receptor antagonist (Ki = 250 nM). Pretreatment with meclizine (2.5-30 mg/kg, i.p.) reduces ovalbumin-induced mast cell degranulation, edema, and leukocyte influx in rat lung. Formulations containing meclizine have been used in the treatment of motion sickness and vertigo.
용도Meclizine Dihydrochloride is a histamine H1 receptor antagonist with antiemetic properties. Meclizine Dihydrochloride is a research product for neuroscience. This compound may exhibit neuroprotective properties.
상·하류 제품 정보
상류 원료
공급사100 곳
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