기본 정보
- CAS
551-27-9- 표준 SMILES
CCC(Oc1ccccc1)C(=O)N[C@@H]1C(=O)N2[C@@H]1SC(C)(C)[C@@H]2C(=O)O- InChIKey
HOCWPKXKMNXINF-XQERAMJGSA-N- 분자식
- C18H22N2O5S
- 평균 분자량
- 378.4 g/mol
- 단동위원소 질량
- 378.12494298
개요
Propicillin is a penicillin. It is a conjugate acid of a propicillin(1-).
이름 및 식별자
- 우선 이름
- Propicillin
- IUPAC
- (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxybutanoylamino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
- 영어명
- PROPICILLIN
- 분자식
- C18H22N2O5S
- 분자량
- 378.44
이름 및 동의어
Propicillinpropicilline551-27-9PropicilinaPropicillinum(1-Phenoxypropyl)penicillinDTXSID3046291phenoxypropylpenicillinCHEBI:524298X1R260V33DTXCID10262916beta-(2-phenoxybutanamido)-2,2-dimethylpenam-3alpha-carboxylic acid
이름 더 보기
PROPICILLIN USP/EP/BPα-phenoxypropylpenicillin3,3-dimethyl-7-oxo-6-[2-(phenoxy)butanoylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid7-keto-3,3-dimethyl-6-[2-(phenoxy)butanoylamino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid(2S,5β)-3,3-Dimethyl-7-oxo-6α-[(1-oxo-2-phenoxybutyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2β-carboxylic acid4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-[(1-oxo-2-phenoxybutyl)amino]-, (2S,5R,6R)-
PropibayRefChem:176404ALPHA-PHENOXYPROPYLPENICILLIN208-995-5(2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenoxybutanoylamino)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.alpha.-phenoxypropylpenicillin(2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenoxybutanamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid(2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(2-phenoxybutanoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
물성
구조 계산 물성
- XLogP
- 2.7
- 극성 표면적
- 121 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 26
- 형식 전하
- 0
- 복잡도
- 590
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Antibiotics
Human DrugsPharmaceuticals
물리화학적 성질
- 산도 계수 (pKa)
- 2.72 · pKa 2.72±0.04(H2O t=25 c=0.01) (Uncertain)
화학 및 산업
약리 정보
ATC Code
J - Antiinfectives for systemic use
QJ - Antiinfectives for systemic use
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
용도 및 제조
UsesUse (kg; approx.) in Germany (2009): >500
Use ClassificationPharmaceuticals
응용 분야
개요Propicillin was synthesized by a collaboration of Beecham Research Laboratories with Bristol-Myers Laboratories in 1961 starting with 6-aminopenicillanic acid. It is stable against gastric acid and shows three- to fourfold higher serum concentrations than phenoxymethyl-penicillin when administered orally. Its antibacterial spectrum and activity are almost the same as those of phenoxymethylpenicillin. Propicillin has been used for therapy of infections caused by Streptococcus, Staphylococcus, and Neisseria.
용도Propicillin, is a derivative of penicillin. Properties are similar to benzylpenicillin particularly used in streptococcal infections, not resistant to penicillinase.
공급사2 곳
BOC Sciences16314854226 · [email protected]
陕西缔都医药化工有限公司+86-29-81139210 +86-17392587031 · [email protected]
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