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3,3'-디티오디프로피온산DI(N-석신이미딜에스테르)

3,3'-Dithiobis(succinimidyl propionate)

HCID 93313
노트반응
기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트
부분 구조 검색유사 구조 찾기

기본 정보

CAS
57757-57-0
표준 SMILES
O=C(CCSSCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O
InChIKey
FXYPGCIGRDZWNR-UHFFFAOYSA-N
분자식
C14H16N2O8S2
평균 분자량
404.4 g/mol
단동위원소 질량
404.03480782

개요

used to study interactions of structural proteins; RN given refers to unlabeled cpd

이름 및 식별자

우선 이름
3,3'-Dithiobis(succinimidyl propionate)
IUPAC
(2,5-dioxopyrrolidin-1-yl) 3-[[3-(2,5-dioxopyrrolidin-1-yl)oxy-3-oxopropyl]disulfanyl]propanoate
현지명
3,3'-디티오디프로피온산DI(N-석신이미딜에스테르)
영어명
3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester)
분자식
C14H16N2O8S2
분자량
404.42

이름 및 동의어

57757-57-0Disuccinimido dithiobispropionateDTSPLomant's reagentDithiobis(succinimidylpropionate)EVY5D0U6SH3,3'-DITHIO(SUCCINIMIDYL PROPIONATE)NSC-3283863,3'-dithiobis(succinimidyl propionate)2,5-Pyrrolidinedione, 1,1'-(dithiobis((1-oxo-3,1-propanediyl)oxy))bis-DTXSID002064492,5-Pyrrolidinedione, 1,1'-[dithiobis[(1-oxo-3,1-propanediyl)oxy]]bis-
이름 더 보기
3,3'-디티오디프로피온산DI(N-석신이미딜에스테르)DSPDITHIOBIS(SUCCINIMIDYL PROPIONATE)DI(N-SUCCINIMIDYL) 3,3'-DITHIODIPROPIONATESULFO-DSSNSC 328386LOMANTS REAGENTDSP CrosslinkerDSS, WATER-SOLUBLE
3,3'-DITHIOBIS(N-HYDROXYSUCCINIMIDYLPROPIONATE)BIS(2-((SUCCINIMIDYLOXY)CARBONYL)ETHYL) DISULFIDE3,3'-DITHIOLDIPROPIONIC ACID BIS(N-HYDROXYSUCCINIMIDE ESTER)PROPANOIC ACID, 3,3'-DITHIOBIS-, 1,1'-BIS(2,5-DIOXO-1-PYRROLIDINYL) ESTERDSP cross linkerDTBSPRefChem:135192dithiobis(succinimidyl-propionate)

물성

구조 계산 물성

XLogP
-1.2
극성 표면적
178 Ų
수소 결합 공여자 수
0
수소 결합 수용자 수
10
회전 가능 결합 수
11
무거운 원자 수
26
형식 전하
0
복잡도
552

실험 및 물리화학적 성질

Chemical ClassesOther Classes -> Sulfur Compounds
Physical DescriptionWhite powder; [Sigma-Aldrich MSDS]

물리화학적 성질

녹는점
128 · 128-133 °C
끓는 점
560.1 · 560.1±60.0 °C(Predicted)
밀도
1.57 · 1.57±0.1 g/cm3(Predicted)
저장 조건
-20 °C · -20°C
용해도
50 mg/mL · 클로로포름: 50mg/mL
물리적 상태
가루
색상
회백색
BRN
1518074 · 1518074
InChI
InChI=1S/C14H16N2O8S2/c17-9-1-2-10(18)15(9)23-13(21)5-7-25-26-8-6-14(22)24-16-11(19)3-4-12(16)20/h1-8H2
InChIKey
FXYPGCIGRDZWNR-UHFFFAOYSA-N
SMILES
S(CCC(ON1C(=O)CCC1=O)=O)SCCC(ON1C(=O)CCC1=O)=O

화학적 성질

Off-White Solid

안전 및 규제

안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.

GHS 분류

GHS Classification · 4건

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 42 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

유해성 정보

Hazards SummaryA skin and strong eye irritant; May cause CNS depression; [Sigma-Aldrich MSDS] See 2-Hydroxyethyl disulfide. See Disuccinimidyl oxalate.
Hazard Classes and CategoriesSkin Irrit. 2 (100%)

안전 데이터

wgk
3
HS 번호
29309090
risk_code
36/37/38
hazard_code
Xi
safety_code
26-36
F 고인화성물질
10-21
Hazard Classifications
Eye Irrit. 2Skin Irrit. 2STOT SE 3
스토리지 클래스
11 - Combustible Solids

화학 및 산업

약리 정보

MeSH Pharmacological Classification · 2건

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

용도 및 제조

UsesUsed to study interactions of structural proteins. [ChemIDplus]
응용 분야 · 2건

용도3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) can be used in the crosslinking of intracellular proteins prior to cell lysis.

일반 설명3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester) (DSP) is a homobifunctional cross-linking reagent containing a cleavable disulfide linkage. It is typically coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5).

상·하류 제품 정보

상류 원료

3,3′-디시오 디프로피오닉 산디(N-숙신이미딜)카보네이트

관련 반응

1건
반응 기록 만들기
HRID 882649 반응식
HRID 882649반응물로uspto-grants-2015_03

화합물 노트

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이 페이지에서기본 정보개요이름 및 식별자물성안전 및 규제화학 및 산업관련 반응화합물 노트

데이터베이스 식별자

CAS
57757-57-0
PubChem CID
93313
DTXSID
DTXSID00206449
UNII
EVY5D0U6SH
EC Number
260-931-5
Nikkaji
J227.548A
N-히드록시석신이미드
디클로로메탄
N-(3-디메틸아미노프로필)-N'-에틸카르보디이미드염산염
3-메르캅토프로피온산

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