기본 정보
- CAS
60-25-3- 표준 SMILES
C[N+](C)(C)CCCCCC[N+](C)(C)C.[Cl-].[Cl-]- InChIKey
PYIHTIJNCRKDBV-UHFFFAOYSA-L- 분자식
- C12H30Cl2N2
- 평균 분자량
- 273.28 g/mol
- 단동위원소 질량
- 272.1786044
개요
See also: Hexamethonium (has active moiety); Hexamethonium Bromide (related); Hexamethonium Iodide (related).
이름 및 식별자
- 우선 이름
- Hexamethonium Chloride
- IUPAC
- trimethyl-[6-(trimethylazaniumyl)hexyl]azanium dichloride
- 현지명
- 헥사메토늄클로라이드
- 영어명
- HEXAMETHONIUM CHLORIDE
- 분자식
- C12H30Cl2N2
- 분자량
- 273.29
이름 및 동의어
Hexamethonium chloride60-25-3Hexamethonium dichlorideHestrium chlorideDTXSID3044700TIV4Q933FUHexamethylene(bistrimethylammonium)chlorideN,N,N,N',N',N'-hexamethylhexane-1,6-diaminium dichlorideDTXCID1024700NSC-216431,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, chloride (1:2)NSC21643
이름 더 보기
헥사메토늄클로라이드헥사메토늄클로라이드헥사메틸렌(비스트라이메틸암모늄)클로라이드hexonchloridehiohexchloridehexonechlorideesomidchloridemethiumchloridebistriumchloridehestriumchloride
Chloride, HexamethoniumRefChem:146066200-465-1DepressinChloor-hexavietEsomid chlorideHexone chlorideHiohex chloride
데이터베이스 식별자
- CAS
60-25-3- PubChem CID
- 93550
물성
구조 계산 물성
- 극성 표면적
- 0 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 16
- 형식 전하
- 0
- 복잡도
- 121
실험 및 물리화학적 성질
Physical DescriptionLiquid
물리화학적 성질
- 녹는점
- 292 °C · 292°C(dec.)(lit.)
- 끓는 점
- 423.36 °C · 423.36°C (rough estimate)
- 밀도
- 1.0558 · 1.0558 (rough estimate)
- 굴절률
- 1.64 · 1.6400 (estimate)
- 용해도
- 2 O: · H2O: 용해성
- 물리적 상태
- 고체(흡습성)
- 색상
- 하얀색
- 수용성
- 거의 투명함
- BRN
- 3714806 · 3714806
- InChI
- 1S/C12H30N2.2ClH/c1-13(2,3)11-9-7-8-10-12-14(4,5)6;;/h7-12H2,1-6H3;2*1H/q+2;;/p-2
- InChIKey
- PYIHTIJNCRKDBV-UHFFFAOYSA-L
- SMILES
- [Cl-].[Cl-].C[N+](C)(C)CCCCCC[N+](C)(C)C
- EPA
- 1 · 1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dichloride (60-25-3)
화학적 성질
White, crystalline, hygroscopic powder; faint odor. Very soluble in water; soluble in alcohol, methanol, and n-propanol; insoluble in chloroform and ether. Available commercially as unhydrated form or as dihydrate.
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (104 of 104) of all reports.
Not Classified
Aggregated GHS information provided per 104 reports by companies from 1 notifications to the ECHA C&L Inventory.
유해성 정보
Regulatory Information
1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, chloride (1:2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, chloride (1:2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Hexamethonium chloride (EC: 200-465-1)
Hazard Classes and CategoriesNot Classified
안전 데이터
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- BQ8650000
- HS 번호
- 2923.90.0100
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents having as their major action the interruption of neural transmission at nicotinic receptors on postganglionic autonomic neurons. Because their actions are so broad, including blocking of sympathetic and parasympathetic systems, their therapeutic use has been largely supplanted by more specific drugs. They may still be used in the control of blood pressure in patients with acute dissecting aortic aneurysm and for the induction of hypotension in surgery.
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
용도 및 제조
U.S. Production2023: 50,000 - <250,000 lb
Industry UsesIntermediate
General Manufacturing Information
All Other Basic Organic Chemical Manufacturing
1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, chloride (1:2): ACTIVE
응용 분야
용도Hexamethonium Chloride is a ganglionic nicotinic receptor blocker.
일반 설명Nicotinic acetylcholine receptor (nAChR) forms a ligand-gated ion channel made up of four different subunits. Each subunit contains an extracellular amino-terminal domain (hydrophilic) and carboxylic terminal domain and four transmembrane domains. nAChR is an allosteric and transmembrane protein localized to the neuromuscular junction.
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