기본 정보
- CAS
306-07-0- 표준 SMILES
C#CCN(C)Cc1ccccc1.Cl- InChIKey
BCXCABRDBBWWGY-UHFFFAOYSA-N- 분자식
- C11H14ClN
- 평균 분자량
- 195.69 g/mol
- 단동위원소 질량
- 195.0814771
개요
Pargyline Hydrochloride is the hydrochloride salt form of pargyline, a monoamine oxidase (MAO) inhibitor with antidepressant activity. Pargyline selectively inhibits MAO type B, an enzyme catalyzing the oxidative deamination and inactivation of certain catecholamines, such as norepinephrine and dopamine, within the presynaptic nerve terminals. By inhibiting the metabolism of these biogenic amines in the brain, pargyline increases their concentration and binding to postsynaptic receptors. Increased receptor stimulation may cause downregulation of central receptors which may attribute to pargyline's antidepressant effect.
이름 및 식별자
- 우선 이름
- Pargyline Hydrochloride
- IUPAC
- N-benzyl-N-methylprop-2-yn-1-amine;hydrochloride
- 영어명
- Pargyline hydrochloride
- 분자식
- C11H14ClN
- 분자량
- 195.69
이름 및 동의어
Pargyline hydrochloride306-07-0Pargyline HClEutonylN-Methyl-N-2-propynylbenzylamine hydrochlorideMO-911DTXSID1044647W70V6I2OMYNSC-43798A-19120DTXCID9024647NSC43798
이름 더 보기
NSC 43798Parguline HCLpargylinechloridePARGYLINE HYDROCHLORParglycine hydrochloridePargylamine hydrochloridePargyline Hydrochloride (200 mg)PARGYLINE HYDROCHLORIDE USP/EP/BP
RefChem:58612206-175-1N-Methyl-N-propargylbenzylamine hydrochlorideN-benzyl-N-methylprop-2-yn-1-amine hydrochlorideEutonyl-tenPargyline chlorideMFCD00012492USAF A-19120
데이터베이스 식별자
- CAS
306-07-0- PubChem CID
- 9373
- DTXSID
DTXSID1044647- ChEMBL
CHEMBL1200425- UNII
- W70V6I2OMY
- EC Number
- 206-175-1
물성
구조 계산 물성
- 극성 표면적
- 3.2 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 1
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 13
- 형식 전하
- 0
- 복잡도
- 159
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section134.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
물리화학적 성질
- 녹는점
- 160 · 160-163 °C(lit.)
- 저장 조건
- -20 °C · -20°C
- 용해도
- 33.55 mg/mL · ≥33.55 mg/mL in EtOH; ≥51.6 mg/mL in H2O; ≥7.55 mg/mL in DMSO
- 물리적 상태
- 결정성 고체
- 색상
- 2 O에서 · EtOH/Et2O에서 결정화
- 생물학적 소스
- synthetic
- 수용성
- 50 mg/mL, · water: 50mg/mL, clear, colorless to faintly yellow
- Merck
- 13 · 13,7110
- BRN
- 3699487 · 3699487
- InChI
- InChI=1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H
- InChIKey
- BCXCABRDBBWWGY-UHFFFAOYSA-N
- SMILES
- C1(=CC=CC=C1)CN(C)CC#C.Cl
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P264, P270, P301+P316, P321, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 183 reports by companies from 1 notifications to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 3 (100%)
안전 데이터
- wgk
- 3
- rtecs
- DP6650000
- ridadr
- UN 2811 6.1/PG 3
- 독성
- LD50 orl-rat: 250 mg/kg 27ZQAG -,401,72
- HS 번호
- 2921199990
- risk_code
- 22
- hazard_code
- Xn
- safety_code
- 22-24/25
- 포장분류
- III
- 위험 등급
- 6.1(b)
- F 고인화성물질
- 10
- Hazard Classifications
- Acute Tox. 3 Oral
- 스토리지 클래스
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)
응용 분야
용도Pargyline hydrochloride has been used: as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats, to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum
상·하류 제품 정보
상류 원료
공급사100 곳
北京华美互利生物化工010-56205725 · [email protected]
陕西科贝莱药物研发有限公司13119135307 13119135307 · [email protected]
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