기본 정보
- CAS
316-41-6- 표준 SMILES
COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.COc1ccc2cc3[n+](cc2c1OC)CCc1cc2c(cc1-3)OCO2.O=S(=O)([O-])[O-]- InChIKey
OJVABJMSSDUECT-UHFFFAOYSA-L- 분자식
- C40H36N2O12S
- 평균 분자량
- 768.8 g/mol
- 단동위원소 질량
- 768.19889576
개요
See also: Berberine (annotation moved to).
이름 및 식별자
- 우선 이름
- Berberine sulfate anhydrous
- IUPAC
- bis(16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-1(13),2,4(8),9,14,16,18,20-octaene);sulfate
- 영어명
- BERBERINE SULFATE TRIHYDRATE
- 분자식
- C20H18NO8S-
- 분자량
- 432.42
이름 및 동의어
Berberine sulphateBerberin sulfateBerberine sulfate (2:1)Neutral berberine sulfateErbenBerberine sulfate anhydrousFST3E667FFBenzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, sulfate (2:1)Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydr0-9,10-dimethoxy-, sulfate (2:1)Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, sulfate (2:1)NSC-5355RefChem:1079543
이름 더 보기
fate(2:1)berberinsuulfate(2:1)berberinsulfateberberinesulfate(2:1)Berberine sulfate 98%Beriberisulfatehydrateneutralberberinesulfate
206-258-2Berberine sulfateBerberine hemisulfate6190-33-6BerberalBerberine sulfate hydrateAI3-61947Berberine.sulfate.3H20
데이터베이스 식별자
물성
구조 계산 물성
- 극성 표면적
- 170 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 12
- 회전 가능 결합 수
- 4
- 무거운 원자 수
- 55
- 형식 전하
- 0
- 복잡도
- 551
실험 및 물리화학적 성질
Color/FormYELLOW CRYSTALS
SolubilityINSOL IN CHLOROFORM /TRIHYDRATE/
DecompositionDISASTER HAZARD: DANGEROUS; WHEN HEATED TO DECOMPOSITION, EMITS HIGHLY TOXIC FUMES. /BERBERINE/
Other Experimental Properties
RED-YELLOW NEEDLES /TRIHYDRATE/
YELLOW NEEDLES /TRIHYDRATE/
SOLUBLE IN ABOUT 30 PARTS WATER, IN ALC /TRIHYDRATE/
물리화학적 성질
- 저장 조건
- Inert atmosphere,Room Temperature
- 물리적 상태
- powder to crystal
- 색상
- 황백색 내지 황색 분말
- 수용성
- 거의 투명함
- Merck
- 14 · 14,1154
- InChIKey
- OJVABJMSSDUECT-UHFFFAOYSA-L
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
P261, P262, P264, P270, P271, P280, P301+P316, P302+P352, P304+P340, P316, P321, P330, P361+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
The GHS information provided by 1 company from 1 notification to the ECHA C&L Inventory.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 3 (100%)
독성 정보
Human Toxicity Excerpts
TOXIC DOSES DEPRESS HEART (DIRECTLY & REFLEXLY THROUGH THE VAGUS), RELAX BLOOD VESSELS, DEPRESS RESPIRATIONS, & STIMULATE SMOOTH MUSCLE IN INTESTINES, BRONCHI, & POSSIBLY UTERUS. /BERBERINE/
AN ALKALOID POISON. IN TOXIC DOSES IT LOWERS TEMPERATURE, INCREASES PERISTALSIS, AND CAUSES DEATH BY CENTRAL PARALYSIS. /BERBERINE/
TOXIC BY INGESTION, INHALATION, AND SKIN ABSORPTION. /BERBERINE/
Non-Human Toxicity Excerpts
HISTOPATHOLOGICAL EXAM REVEALED NO CHANGES IN TISSUES & ORGANS OF RATS EVEN IN CASES WHEN BERBERINE SULFATE WAS GIVEN FOR 6 WK IN 0.5 G/KG DAILY ORAL DOSES.
BERBERINE SULFATE (10-15 MG/KG, IP) DEPRESSED CNS AND CAUSED LACRIMATION, PILOMOTOR ERECTION, & PTOSIS IN MICE. IT CAUSED A MARKED TAMING EFFECT AS EVIDENCED BY BODY GRASP & HEAD TAP TEST. PENTOBARBITONE SLEEPING TIME WAS MARKEDLY INCREASED.
ORALLY ADMIN BERBERINE SULFATE SHOWED LOW TOXICITY DUE TO POOR ABSORPTION FROM DIGESTIVE TRACT. IP ADMIN RESULTED IN HIGH TOXICITY.
Probable Routes of Human ExposureSHOULD NOT BE HANDLED EXCESSIVELY, SINCE IT MAY BE ABSORBED THROUGH THE SKIN AND HAVE TOXIC EFFECT UPON THE BODY. /BERBERINE/
화학 및 산업
약리 정보
Absorption, Distribution and Excretion...MAY BE ABSORBED THROUGH THE SKIN... /BERBERINE/
용도 및 제조
UsesMEDICATION
General Manufacturing Information
/BERBERINE IS/ ALKALOID, USUALLY AS SULFATE; OBTAINED FROM RHIZOMES AND ROOTS OF HYDRASTIS CANADENSIS.
/BERBERINE/...BEHAVES AS A QUATERNARY BASE, FORMING SALTS BY REPLACEMENT OF THE OH GROUP: PERKIN, JR, J CHEM SOC 113, 503 (1918). /BERBERINE/
응용 분야
용도Various beneficial effects on the cardiovascular system and significant anti-inflammatory activities.Berberine has been shown to lower elevated blood glucose as effectively as metformin.Berberine seems to act as an herbal antidepressant and a neuroprotect
공급사100 곳
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖北威德利化学试剂有限公司186-02735115 18062128043 · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
成都彼样生物科技有限公司
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