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HCID 9502생성일: 2026년 10월 23일

리누론

리누론 · 3-(3,4-디클로로페닐)-1-메톡시메틸우레아 · N'-(3,4-디클로로페닐)-N-메톡시-N-메틸우레아 · PROVIGIL · TELIRON · Liron · LOROX · LINEX

https://huagongshe.com/ko/chemical/9502

리누론 분자 구조식

식별자 및 물리적 특성

CAS No.330-55-2
분자식C9H10Cl2N2O2
평균 분자량249.09 g/mol
단동위원소 질량248.011933 g/mol
SMILESCON(C)C(=O)Nc1ccc(Cl)c(Cl)c1
InChIKeyXKJMBINCVNINCA-UHFFFAOYSA-N
PubChem CID9502
ChEMBLCHEMBL448213
ChEBICHEBI:6482
EC No.206-356-5
DTXSIDDTXSID2024163
현지명리누론

화학 및 물리적 성질

XLogP3.2
극성 표면적41.6
수소 결합 공여자 수1
수소 결합 수용자 수2
회전 가능 결합 수2
무거운 원자 수15
형식 전하0
복잡도228
LogP(분배 계수)log Kow=3.20
냄새ODORLESS
밀도1.49 @ 20 °C1.4909 (rough estimate)
Color/FormWhite crystalline solidColorless crystalsFine flakes or coarse powder
용해도PARTIALLY SOL IN TOLUENESPARINGLY SOL IN ALIPHATIC HYDROCARBONSIn acetone 500, benzene 150, ethanol 150, xylene 130, n-heptane 15 (all in g/kg at 25 °C). Readily soluble in dimethylformamide, chloroform, and diethyl ether. Moderately soluble in aromatic hydrocarbons. Sparingly soluble in aliphatic hydrocarbons.In water, 75 mg/l @ 25 °CSolubility in water, g/100ml:DMSO : 100 mg/mL (401.46 mMNeed ultrasonic)
CorrosivityNon-corrosive
DecompositionWhen heated to decomposition it emits very toxic fumes of /hydrogen chloride and nitrogen oxides/.
녹는점93-94 °C93-94°C
증기압0.00000143 [mmHg]1.43X10-6 mm Hg @ 25 °CVapor pressure, Pa at 24 °C: 0.002
헨리 상수Henry's Law constant= 1.97X10-9 atm-cu m/mol @ 25 °C1.6×103 mol/(m3Pa) at 25℃, Duchowicz et al. (2020)
Physical DescriptionLinuron appears as colorless crystals. Non corrosive. Used as an herbicide.Colorless or white odorless solid[HSDB] Colorless odorless fine crystalline powder[MSDSonline]COLOURLESS CRYSTALS.
Stability/Shelf LifeIt is stable at its melting point & in neutral aqueous media.DRY FORMULATIONS ARE STABLE UNDER NORMAL STORAGE CONDITIONS.Hydrolyzed slowly by acids and alkalis at normal temperatures, and more rapidly at higher temperatures.
끓는 점180-190°C
굴절률1.6100 (estimate)
인화점11 °C
저장 조건APPROX 4°C
물리적 상태결정질 고체
pKa(산도 계수)12.13±0.70(Predicted)
색상하얀색
용해도0.0075g/100mL
BRN2128725
주요 응용농업청소용품화장품환경음식 및 음료개인 위생 관리
InChI1S/C9H10Cl2N2O2/c1-13(15-2)9(14)12-6-3-4-7(10)8(11)5-6/h3-5H,1-2H3,(H,12,14)
InChIKeyXKJMBINCVNINCA-UHFFFAOYSA-N
SMILESCON(C)C(=O)Nc1ccc(Cl)c(Cl)c1
NISTN'-(3,4-Dichlorophenyl)-N-methoxy-N-methylurea(330-55-2)
EPALinuron (330-55-2)

화학적 성질

White crystalline solid or powder. Odorless. Commercial product may be available a water soluble or emulsifiable concentrate.

안전 및 규제

GHS 분류DangerH302: Harmful if swallowed [Warning Acute toxicity, oral]H351: Suspected of causing cancer [Warning Carcinogenicity]H360Df: May damage the unborn childSuspected of damaging fertility [Danger Reproductive toxicity]H373 **: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]P203, P260, P264, P270, P273, P280, P301+P317, P318, P319, P330, P391, P405, and P501 (click each P-code to see the statement)
규제 정보Hazard Traits - Developmental ToxicityReproductive ToxicityAuthoritative List - EC Annex VI CMRs - Cat. 1BProp 65Report - regardless of intended function of ingredient in the productCommission Regulation No 844/2012Linuron is listed in the dataset of EPA Human Health Benchmarks for Pesticides under the Safe Drinking Water Act (40 eCFR 141)03/31/EC, Reg (EU) 2015/408, Reg. (EU) 2016/950, Reg. (EU) 2017/244, Reg. (EU) No 540/2011, Reg. (EU) No 823/2012Linuron: Does not have an individual approval but may be used under an appropriate group standardThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
기타 안전 정보IMAP assessments - Urea, N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl-: Environment tier I assessmentIMAP assessments - Urea, N'-(3,4-dichlorophenyl)-N-methoxy-N-methyl-: Human health tier I assessment
운송 라벨(DOT)Class 9
화재 위험Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Some may burn but none ignite readily. Containers may explode when heated. Some may be transported hot. For UN3508, Capacitor, asymmetric, be aware of possible short circuiting as this product is transported in a charged state. Polymeric beads, expandable (UN2211) may evolve flammable vapours. (ERG, 2024)Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire.
건강 유해성Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Inhalation of material may be harmful. Contact may cause burns to skin and eyes. Inhalation of Asbestos dust may have a damaging effect on the lungs. Fire may produce irritating, corrosive and/or toxic gases. Some liquids produce vapors that may cause dizziness or asphyxiation. Runoff from fire control or dilution water may cause environmental contamination. (ERG, 2024)
유해성 요약May cause skin, eye, nose, and throat irritationUrea-derived herbicides have low toxicity in animal feeding studiesMay induce methemoglobinemia[HSDB] Systemic toxicity unlikely unless large amounts ingested[EPA Pesticides, p. 122] May effect blood causing anemia[ICSC] May cause irritation[MSDSonline] May interfere with fertility in rats because of its antiandrogenic effects[REPROTOX]
반응성 그룹Amides and ImidesAryl HalidesAmines, Aromatic
EC 분류Symbol: T, NR: 61-22-40-48/22-62-50/53S: 53-45-60-61
FIFRA 요건As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Linuron is found on List A, which contains most food use pesticides and consists of the 194 chemical cases (or 350 individual active ingredients) for which EPA issued registration standards prior to FIFRA, as amended in 1988. Case No: 0047Pesticide type: herbicideRegistration Standard Date: 06/29/84Case Status: RED Approved 12/94OPP has made a decision that some/all uses of the pesticide are eligible for reregistration, as reflected in a Reregistration Eligibility Decision (RED) document.Active ingredient (AI):LinuronData Call-in (DCI) Date(s): 09/04/90, 11/08/93, 04/28/95AI Status: OPP has completed a Reregistration Eligibility Decision (RED) document for the case/AI.Tolerances are established for residues of the herbicide linuron (3-(3,4-dichlorophenyl)-1-methoxy-1-methylurea) in or on the following food commodities: asparaguscarrotscattle, fatcattle, mbypcattle, meatcelerycorn, field, foddercorn, field, foragecorn, fresh (inc. sweet K+CWHR)corn, grain (inc. pop)corn, sweet, foddercorn, sweet, foragecottonseedgoats, fatgoats, mbypgoats, meathogs, fathogs, mbyphogs, meathorses, fathorses, mbyphorses, meatparsnips (with or without tops)potatoessheep, fatsheep, mbypsheep, meatsorghum, foddersorghum, foragesorghum, grain (milo)soybeans (dry and succulent)soybeans, foragesoybeans, haywheat, foragewheat, grainwheat, hayand wheat, straw.Tolerances with regional registration, as defined in 180.1(n), are established for residues of the herbicide linuron 3-(3,4- dichlorophenyl)-1-methoxy-1-methylurea in or on the following food commodity: parsley.
Reactivity ProfileA urea derivative.
Chemical DangersDecomposes on heating. This produces toxic fumes including hydrogen chloride and nitrogen oxides.
Packaging and LabellingDo not transport with food and feedstuffs.
소화Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:CAUTION: Fire involving Safety devices (UN3268) and Fire suppressant dispersing devices (UN3559) may have a delayed activation and a risk of hazardous projectiles. Extinguish the fire at a safe distance.SMALL FIRE: Dry chemical, CO2, water spray or regular foam.LARGE FIRE: Water spray, fog or regular foam. Do not scatter spilled material with high-pressure water streams. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal.FIRE INVOLVING TANKS: Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. (ERG, 2024)Use water spray, powder, foam, carbon dioxide.
응급 조치Fresh air, rest.Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Rest. Refer for medical attention .
응급 처치Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Refer to the "General First Aid" section. (ERG, 2024)
안전 보관Provision to contain effluent from fire extinguishing. Separated from food and feedstuffs.
보관 조건Store in cool, dry place ... .
비화재 누출 대응Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. For Asbestos, avoid inhalation of dust. Cover spill with plastic sheet or tarp to minimize spreading. Do not clean up or dispose of, except under supervision of a specialist.SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover looselymove containers from spill area.SMALL SPILL: Pick up with sand or other non-combustible absorbent material and place into containers for later disposal.LARGE SPILL: Dike far ahead of liquid spill for later disposal. Cover powder spill with plastic sheet or tarp to minimize spreading. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2024)
처리 방법SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.Linuron should be incinerated in a unit operating at 850 °C equipped with offgas scrubbing equipment. ... Recommendable methods: Incineration.
누출 처리Do NOT wash away into sewer. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations. Personal protection: self-contained breathing apparatus.
Preventive MeasuresAVOID BREATHING DUST OR SPRAY MIST. AVOID CONTACT WITH SKIN, EYES, & CLOTHING.Wash contaminated clothing with soap & hot water before re-use.Avoid contact with skin, eyes, and clothing. ... Keep out of lakes, streams, or ponds.SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Isolation and EvacuationExcerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directionsalso, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Eye PreventionWear safety spectacles.
Fire PreventionNO open flames.
표적 장기Hematologic
건강 영향Linuron affects the male reproductive system of the offspring after maternal exposure during mid and late pregnancy.
생태독성 수치LC50 RAINBOW TROUT 16 PPM/96 HRLC50 BLUEGILL 16 PPM/96 HRLC50 RING NECKED PHEASANT ORAL 3438 PPM, AGE 10 DAYS (95% CONFIDENCE LIMIT 2874-4139 MG/L) /50% PURE/LC50 MALLARD ORAL 3083 PPM, AGE 5 DAYS (95% CONFIDENCE LIMIT 2419-3990 MG/L) /50% PURE/For more Ecotoxicity Values (Complete) data for LINURON (6 total), please visit the HSDB record page.
환경 거동TERRESTRIAL FATE: Based on a classification scheme(1), a Koc value ranging from 555 to 987(2), indicates that linuron is expected to have low mobility in soil(SRC). Volatilization of linuron from moist soil surfaces is not expected to be an important fate process(SRC) given an experimental Henry's Law constant of 1.97X10-9 atm-cu m/mol(3). Linuron is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure of 1.43X10-6 mmHg(4). The dissipation of linuron was followed in field plots planted with potatoes and treated at 1 and 2 kg/ha(5). The disappearance of linuron was very fast and followed first-order kinetics with a half-life of 25 and 22 days, respectively, at the two application rates. After about 75 days, the residual concentration of linuron in the soil was constant, suggesting that a small amount of linuron is strongly absorbed to soil colloids and not available to microbial attack(5). Most evidence indicates that linuron's loss in soil is due to biodegradation(6). For example linuron, at 4 ppm, degraded with half-lives of 22-86 days when incubated at 25 °C in 18 mineral soils(7). Photolysis of linuron on surface soils may also be an important degradation pathway. Phenyl-labeled C-14 linuron degraded with a half-life >15 days on silt loam soil irradiated continuously with a Pyrex glass filtered xenon arc light at 25 deg(8). After 15 days of irradiation, the soil contained 78.8% of the recovered radioactivity as parent linuron.TERRESTRIAL FATE: The half-life of linuron in cropped fields was 8-25 weeksresidues were undetectable after 6 mo(1-2). No progressive buildup was observed after repeated treatment(1-2). Four weeks after a half normal, normal, and double normal spray of linuron in May on corn, carrots, bean and potato crops planted in loamy soil, an average of 40% of the applied dose was recovered(3). After 3 months, only 25% of the linuron was recovered(3). At the end of the winter months, <0.4% of the linuron was recovered(3). In Greenhouse experiments linuron's persistence was 25-60 weeks(3). In test field plots in a vegetable growing area of Ontario, 64% of linuron had dissipated in 5 months from the organic soil (92% organic matter)(4). It was concluded that linuron residues did not accumulate in soil in vegetable farms of area growers(4).AQUATIC FATE: Based on a classification scheme(1), an experimental Koc value ranging from 555 to 987(2), indicates that linuron is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon a Henry's Law constant of 1.97X10-9 atm-cu m/mole(4). According to a classification scheme(5), a BCF ranging from 13 to 49(6,7), suggests the potential for bioconcentration in aquatic organisms is low to moderate. Hydrolysis of linuron is not expected to occur in water except at high alkaline conditions (pH> 9)(8). There was no evidence of hydrolysis products after 4 months in buffered solutions at pH 5, 7, and 9(8). Biodegradation of linuron in surface waters appears to be site specific. Although linuron did not biodegrade when incubated with river water and sewage for 4 months(8), when it was applied as an emulsifiable formulation to ditch water, it degraded with half-lives ranging from 7.2 to 11.8 days during the stagnant period (1 week), and an average half-life of 3.8 days during the flow period (3 weeks)(9). Disappearance of linuron was slower in the higher treatment rate ditches, and in those studied during lower temperature periods(9). Photolysis of linuron is expected to occur in surface waters. In one experiment, 43% of linuron exposed to sunlight outdoors was photolyzed in 24 days(8). After 1 ppm of linuron was added to each of three 1 cu m outdoor ecosystems, linuron concns in the water columns declined exponentially over the 42-day experimentthe calculated half-lives ranged from 16 to 42 days(10). The half-life of linuron in Lake Balatan (Hungary) water was 10 weeks(11).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semi-volatile organic compounds in the atmosphere(1), linuron, which has a vapor pressure of 1.43X10-6 mm Hg at 25 °C(2), is expected to exist in both the vapor and particulate phase in the ambient atmosphere. Vapor-phase linuron is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 12 hours(SRC), calculated from its rate constant of 1.0X10-11 cu cm/molecule-sec at 25 °C determined using a structure estimation method(3). Particulate-phase linuron may be removed from the air by wet and dry deposition(SRC). Linuron may undergo photolysis in air based upon its absorption maximas at 210, 245, and 280 nm with some overlap at > 290 nm(4). The rate of photolysis in the environment appears to be slow. Phenyl-labeled C-14 linuron degraded with a half-life > 30 days in sterile aqueous pH 5 buffer solution irradiated with natural sunlight at 25 °C(4).
식품 조사 수치Of the 1044 composites analyzed in the FDA Adult Total Diet Study in FY1978-82, 19 contained linuron(1). In the FY1978-82 FDA'S Adult Total Diet Study Survey, the mean concn of linuron in root vegetable composites was 0.0089 ppm(2). Linuron dietary intakes estimated from the July 1986-April 1991 FDA Total Diet Study were 0.0018 ug/kg body wgt/day for a 6-11 month old0.0024 ug/kg body wgt/day for 2 yr oldand ranged from 0.0005 to 0.0008 ug/kg body wgt/day for respective groups of 14-16 yr, 25-30 yr, and 60-65 yr males and females (3). In a pesticide screening survey of 6970 produce samples, linuron was detected in 226 carrot samples (detection limit = 0.2 ppm)all of the samples containing linuron were carrots(4). Of the 6,568 samples of domestic food and feed the FDA analyzed between 1982 and 1986, 30 (29 of them carrots) contained linuron with levels up to 0.5 ppm(5). None of the 13,283 imported agricultural commodities tested contained linuron(5). No linuron residues (detection limit = 0.1 ppm) were found in 13 potatoes from farms in NJ, 9 from FL, and 3 from CA(6). In a 1994 surveillance study of domestic food samples collected from the U.S. and Puerto Rico, and import food samples from 101 countries, in which 329 pesticides were monitored and only 94 were found, linuron was detected in an unspecified number of samples(7).
유해 작용Methemoglobinemia - The presence of increased methemoglobin in the bloodthe compound is classified as secondary toxic effect
노출 경로The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
독성 요약Linuron is a weak competitive inhibitor of androgen receptor binding and it inhibits androgen-induced gene expression in vitro. This may partially contribute to the malformations of androgen-dependent tissues in male rats. (A9961)
Average Daily IntakeFOOD INTAKE: Assumed 0.0010 ug/kg/d for a 70 kg 14-16 yr male(1). The intake of linuron from the FY1981/82 FDA's Adult Total Diet Study, in which the typical 14-day diet of a 16-19 yr male is collected throughout the US from market basket composite samples in 12 food groups, was 0.004 ug/kg body wt/day(2). An analogous FY 81/82 study for infants and toddlers determined the daily intake of linuron to be 0 and 0.001 ug/kg body wt/day for infants and toddlers, respectively(3). The daily intake of linuron for 6-11 month infants, 2-yr toddlers, 14-16 yr males and 60-65 yr females according to the 1982-1984 FDA Total Diet Study was 0.0010, 0.0014, 0.0004, 0.0005 ug/kg body wt/day, respectively(4). The major source of linuron was carrots(4). Linuron intakes estimated from the 1990 FDA Total Diet Study were 0.0027, 0.0010, and 0.0012 ug/kg/day for a 6-11 month old, a 14-16 yr male, and a 60-65 yr female, respectively(1). Linuron dietary intakes estimated from the July 1986-April 1991 FDA Total Diet Study were 0.0018 ug/kg body wgt/day for a 6-11 month old0.0024 ug/kg body wgt/day for 2 yr oldand ranged from 0.0005 to 0.0008 ug/kg body wgt/day for respective groups of 14-16 yr, 25-30 yr, and 60-65 yr males and females (5).
Acute Toxicity LinkChemical: LINURON
Effluent ConcentrationsRunoff was collected after each rainfall or series of rainfalls from test plots (silty clay loam graded to a slope of 0.2%) planted with soybeans in the 2 to 4 month period following treatment with linuron as a preemergence herbicide. Concns of linuron in runoff in three years were: trace - 28 ppb, trace - 14 ppb, and trace - 124 ppb (trace = <10 ppb), respectively(1).
ICSC Environmental DataThe substance is toxic to aquatic organisms. This substance may be hazardous to the environment. Special attention should be given to algae and aquatic plants. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.
주 식수 지침(MN) MINNESOTA 1 ug/l(FL) FLORIDA 14 ug/l
수질 위해 등급(WGK)3
TSCA 등재 상태TSCA listed
RTECS 번호YS9100000
운송 번호(UN)UN 3077
독성LD50 orally in rats: 1500 mg/kg (Bailey, White)
관세 코드29280000
위험 문구(R)61-22-40-48/22-50/53-62-39/23/24/25-23/24/25-11
위험 표시TN,N,T,F
안전 문구(S)53-45-60-61-36/37-16-7
기존화학 물질KE-10193
위험 등급Acute Tox. 4 OralAquatic Acute 1Aquatic Chronic 1Carc. 2Repr. 1BSTOT RE 2
저장 분류6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
유해 물질 데이터330-55-2(Hazardous Substances Data)
함량 및 규제정보물질구분: 유독물질혼합물(제품)함량정보: 리누론 및 이를 25% 이상 함유한 혼합물
유해화학물질 필터링97-1-61
중점관리물질 필터링별표1-81

용도

개요

Linuron is found as white crystals that have no smell. It is very slightly soluble in water. Linuron can enter the body either by ingestion of contaminated food or water or by dermal contact. Linuron can cause nausea, vomiting, and diarrhea. Eye contact can cause irritation. There is little evidence available as to the effects of exposure to linuron on human health. However, exposure to linuron at normal background levels is unlikely to have any adverse effect on human health.

용도

Linuron is used to control annual and perennial broadleaf and grassy weeds on crop and noncrop sites. It is used as a pre- and post-emergent herbicide. It works by inhibiting photosynthesis in target weed plants. It is used in soybean, cotton, potato, corn, bean, pea, winter wheat, asparagus, carrot, and fruit crops. It is also used on crops stored in warehouses and storerooms. Linuron is classified by the US Environmental Protection Agency (EPA) as a Restricted Use Pesticide (RUP).

일반 설명

Colorless crystals. Non corrosive. Used as an herbicide.

Linuron|Huagongshe