스페르미딘 트리하이드로클로라이드
스페르미딘트리하이드로클로라이드 · 스퍼미딘 트라이하이드로클로라이드 · SPERMIDINE 3HCL · SPERMIDINE HCl · SPERMIDINE HYDROCHLORIDE · N-(3-AMINOPROPYL)-1,4-DIAMINO-BUTANE TRIHYDROCHLORIDE · Spermidie 3HCL · SPD·3HCl
식별자 및 물리적 특성
| CAS No. | 334-50-9 |
|---|---|
| 분자식 | C7H22Cl3N3 |
| 평균 분자량 | 254.6 g/mol |
| 단동위원소 질량 | 253.087931 g/mol |
| SMILES | Cl.Cl.Cl.NCCCCNCCCN |
| InChIKey | LCNBIHVSOPXFMR-UHFFFAOYSA-N |
| PubChem CID | 9539 |
| ChEMBL | CHEMBL1256356 |
| ChEBI | CHEBI:233088 |
| EC No. | 206-379-0 |
| DTXSID | DTXSID0059825 |
| 현지명 | 스페르미딘 트리하이드로클로라이드 |
화학 및 물리적 성질
| 극성 표면적 | 64.1 |
|---|---|
| 수소 결합 공여자 수 | 6 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 7 |
| 무거운 원자 수 | 13 |
| 형식 전하 | 0 |
| 복잡도 | 56.8 |
| 물질 분류 | Other Uses -> Biochemical Research |
| Physical Description | Solid[Merck Index] White hygroscopic powder[Sigma-Aldrich MSDS] |
| 녹는점 | 257-259 °C(lit.) |
| 저장 조건 | room temp |
| 용해도 | H2O: 1 M at 20 °C, 투명, 무색 |
| 물리적 상태 | 결정성 분말 |
| 색상 | 하얀색 |
| pH | 3.0-6.0 (25℃, 1M in H2O) |
| 생물학적 소스 | microbialsynthetic |
| 용해도 | 물(100 mg/ml) 및 에탄올에 용해됩니다. |
| BRN | 3552356 |
| 화장품 원료 기능 | 헤어 컨디셔닝 |
| InChI | InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H23*1H |
| InChIKey | LCNBIHVSOPXFMR-UHFFFAOYSA-N |
| SMILES | C(CCCN)NCCCN.Cl.Cl.Cl |
| EPA | 1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride (334-50-9) |
화학적 성질
Spermidine trihydrochloride appears as white to off-white crystalline powder, which is soluble in water(100mg/ml-clear, colorless solution), very hygroscopic, and air-sensitive.
안전 및 규제
| GHS 분류 | WarningH315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | 1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| 유해성 요약 | Causes convulsions in acute intraperitoneal studies of rats and mice[RTECS] A skin and strong eye irritant[Sigma-Aldrich MSDS] |
| Hazard Classes and Categories | Skin Irrit. 2 (100%) |
| 수질 위해 등급(WGK) | 3 |
| TSCA 등재 상태 | TSCA listed |
| RTECS 번호 | EJ7023000 |
| 관세 코드 | 29212900 |
| 위험 문구(R) | 36/37/38 |
| 위험 표시 | Xi |
| 안전 문구(S) | 26-36 |
| F 고인화성물질 | 3-10 |
| 위험 등급 | Eye Irrit. 2Skin Irrit. 2 |
| 저장 분류 | 11 - Combustible Solids |
용도
개요
Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.
용도
Spermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.
일반 설명
Spermidine trihydrochloride is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.