기본 정보
- CAS
339-44-6- 표준 SMILES
COCCOc1cnc(NS(=O)(=O)c2ccccc2)nc1- InChIKey
QFWPJPIVLCBXFJ-UHFFFAOYSA-N- 분자식
- C13H15N3O4S
- 평균 분자량
- 309.34 g/mol
- 단동위원소 질량
- 309.07832714
개요
Glymidine is a sulfonamide that is N-(pyrimidin-2-yl)benzenesulfonamide which is substituted at position 5 of the pyrimidine ring by a 2-methoxyethoxy group. It is a hypoglycemic drug used for the treatment of diabetes mellitus. It has a role as a hypoglycemic agent. It is a sulfonamide, a member of pyrimidines and a diether. It is a conjugate acid of a glymidine(1-).
이름 및 식별자
- 우선 이름
- Glymidine
- IUPAC
- N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide
- 현지명
- N-[5-(2-메톡시에톡시)피리미딘-2-일]벤젠술폰아미드
- 영어명
- N-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamide
- 분자식
- C13H15N3O4S
- 분자량
- 309.3409
이름 및 동의어
GLYMIDINEGlycodiazineGlidiazine339-44-6GlymidinumN-[5-(2-methoxyethoxy)pyrimidin-2-yl]benzenesulfonamideN-(5-(2-Methoxyethoxy)pyrimidin-2-yl)benzenesulfonamide4C5I4BQZ8FBenzenesulfonamide, N-(5-(2-methoxyethoxy)-2-pyrimidinyl)-DTXSID1023108CHEBI:146188Benzenesulfonamide, N-[5-(2-methoxyethoxy)-2-pyrimidinyl]-
이름 더 보기
N-[5-(2-메톡시에톡시)피리미딘-2-일]벤젠술폰아미드N-[5-(2-methoxyethoxy)-2-pyrimidinyl]benzenesulphonamide
RefChem:144030DTXCID703108206-426-5GlycodiazinN-(5-(2-Methoxyethoxy)-2-pyrimidinyl)benzenesulfonamideN-[5-(2-Methoxyethoxy)-2-pyrimidinyl]benzenesulfonamideN-(5-(2-Methoxyethoxy)-2-pyrimidinyl)benzenesulphonamideGlycodiazin [German]
데이터베이스 식별자
- CAS
339-44-6- PubChem CID
- 9565
- DTXSID
DTXSID1023108- ChEMBL
CHEMBL1697838
물성
구조 계산 물성
- XLogP
- 0.9
- 극성 표면적
- 98.8 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 7
- 회전 가능 결합 수
- 7
- 무거운 원자 수
- 21
- 형식 전하
- 0
- 복잡도
- 385
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
Solubility1.24e-01 g/L
Melting Point220-223
Physical DescriptionSolid
물리화학적 성질
- 녹는점
- 152 · 152-154°
- 저장 조건
- Refrigerator
- 용해도
- 클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 라이트 베이지
화학 및 산업
약리 정보
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Protein Binding90% bound to plasma proteins.
PharmacodynamicsGlycodiazine is used with diet to lower blood glucose by increasing the secretion of insulin from pancreas and increasing the sensitivity of peripheral tissues to insulin.
Mechanism of Action
The mechanism of action of glycodiazine in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells, and increasing sensitivity of peripheral tissues to insulin. Glycodiazine likely binds to ATP-sensitive potassium channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Membrane depolarization stimulates calcium ion influx through voltage-sensitive calcium channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of (pro)insulin.
Biological Half-Life4 hours.
Absorption, Distribution and ExcretionRapidly and completely absorbed following oral administration.
Cellular LocationsMembrane
응용 분야
용도Glymidine is used in biological activities to predict human intestinal absorption in drug discovery.
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