{[(4-oxo-4H-chromen-3-yl)methylidene]amino}thiourea

용도(2E)-2-[(4-Oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide is an intermediate in the synthesis of Akt inhibitor XI (A450500), which inhibits Akt in various cancer cells. Protein kinase B (PKB or Akt) is aserene/threonine kinase, which is involved in a wide variety of cellular processes including metabolism, apoptosis and cell proliferation. Furthermore,Akt inhibitor XIwas employed in a biological study that aimed to develop a novel coiled-coil three-hybrid system that can identify potential allosteric inhibitors.