Nandrolone Decanoate
DECADURABOLIN · Anabolicum · Nandrolone Deconate · Nandrolone Decanoate (DECA) · 19-NORTESTOSTERONE 17-DECANOATE · 17-beta-hydroxy-estr-4-en-3-ondecanoate · retabolil · Nand Deca
식별자 및 물리적 특성
| CAS No. | 360-70-3 |
|---|---|
| 분자식 | C28H44O3 |
| 평균 분자량 | 428.6 g/mol |
| 단동위원소 질량 | 428.32904527 g/mol |
| SMILES | CCCCCCCCCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C |
| InChIKey | JKWKMORAXJQQSR-MOPIKTETSA-N |
| PubChem CID | 9677 |
| ChEMBL | CHEMBL1200946 |
| ChEBI | CHEBI:7467 |
| EC No. | 206-639-3 |
| DTXSID | DTXSID7023352 |
화학 및 물리적 성질
| XLogP | 7.3 |
|---|---|
| 극성 표면적 | 43.4 |
| 수소 결합 공여자 수 | 0 |
| 수소 결합 수용자 수 | 3 |
| 회전 가능 결합 수 | 10 |
| 무거운 원자 수 | 31 |
| 형식 전하 | 0 |
| 복잡도 | 680 |
| 의약품 | Pharmaceuticals -> Synthetic Cannabinoids or Psychoactive CompoundsPharmaceuticals -> Listed in ZINC15 |
| LogP(분배 계수) | 2.62 |
| Human Drugs | FDA approved drugs -> Active ingredientPharmaceuticals |
| Endocrine Disruptors | Potential endocrine disrupting compound |
| 녹는점 | 32-35118 °C33-37°C |
| Physical Description | Solid |
| 끓는 점 | 483.46°C (rough estimate) |
| 밀도 | 1.0406 (rough estimate) |
| 굴절률 | 1.4700 (estimate) |
| 저장 조건 | 2-8°C |
| 용해도 | 45%(w/v) 수성 2-히드록시프로필-β-시클로덱스트린: 0.8mg/mL |
| 물리적 상태 | 가루 |
| 색상 | 흰색에서 밝은 노란색 |
| 용해도 | 664ug/L(37ºC) |
| InChIKey | JKWKMORAXJQQSR-MOPIKTETSA-N |
| SMILES | [C@@]12([H])CC[C@H](OC(=O)CCCCCCCCC)[C@@]1(C)CC[C@]1([H])[C@@]3([H])CCC(=O)C=C3CC[C@@]21[H] |&1:0,4,17,21,23,33,r| |
화학적 성질
White or almost white, crystalline powder.
안전 및 규제
| GHS 분류 | DangerH301 (19.5%): Toxic if swallowed [Danger Acute toxicity, oral]P203, P260, P261, P263, P264, P270, P271, P280, P301+P316, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P362+P364, P405, and P501 (click each P-code to see the statement)Aggregated GHS information provided per 87 reports by companies from 10 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies. |
|---|---|
| 규제 정보 | Nandrolone decanoate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right. |
| 기타 안전 정보 | IMAP assessments - Estr-4-en-3-one, 17-[(1-oxodecyl)oxy]-, (17.beta.)-: Human health tier I assessment |
| Hazard Classes and Categories | Acute Tox. 4 (19.5%) |
| Drug Induced Liver Injury | Drug-Induced Liver Injury Severity and Toxicity (DILIst)nandrolone decanoateDILI PositiveIntramuscularDOI:10.1016/j.drudis.2019.09.022 |
| 수질 위해 등급(WGK) | 3 |
| RTECS 번호 | KG7967000 |
| 독성 | LD50 intraperitoneal in mouse: > 566mg/kg |
| 관세 코드 | 2937290000 |
| 위험 문구(R) | 40 |
| 위험 표시 | Xn |
| 안전 문구(S) | 22-36 |
용도
개요
Nandrolone decanoate, also known as nandrolone caprinate, is an alkylated anabolic steroid indicated in the management of anemia of renal insufficiency and as an adjunct therapy in the treatment of senile and postmenopausal osteoporosis. The process for creating esters of [nandrolone] was patented in Spain in 1959 and in 1960, it was described as having a long duration of action and strong anabolic effect compared to nandrolone and other esters. Nandrolone decanoate was granted FDA approval on 5 October 1962.
용도
Nandrolone Decanoate is an anabolic steroid. Nandrolone decanoate is used in the treatment of osteoporosis in postmenopausal women. Nandrolone Decanoate is also used for some aplastic anemias. Control led Substance.
일반 설명
Nandrolone decanoate,17β-hydroxyestr-4-en-3-one 17-decanoate, has been used inthe management of certain anemias, but the availability oferythropoietin has greatly reduced this use.