Bucladesine

Bucladesin · BUCLADESINE · N-(9-beta-D-Ribofura · Cyclic AMP dibutyrate · Dibutyryl cyclic 3',5'-AMP · Dibutyryl 3',5'-Cyclic AMP · CalciuM Dibutyacyladenosine · 3',5'-Cyclic AMP dibutyrate

https://huagongshe.com/ko/chemical/9687

식별자 및 물리적 특성

CAS No.	362-74-3
분자식	C18H24N5O8P
평균 분자량	469.4 g/mol
단동위원소 질량	469.13624974 g/mol
SMILES	CCCC(=O)Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(O)O[C@H]2[C@H]1OC(=O)CCC
InChIKey	CJGYSWNGNKCJSB-YVLZZHOMSA-N
PubChem CID	9687
ChEMBL	CHEMBL485980
ChEBI	CHEBI:50095
EC No.	206-649-8
DTXSID	DTXSID1040459

화학 및 물리적 성질

XLogP	-0.5
극성 표면적	164
수소 결합 공여자 수	2
수소 결합 수용자 수	11
회전 가능 결합 수	8
무거운 원자 수	32
형식 전하	0
복잡도	759
Collision Cross Section	215.3 Å² [M+H]+ [CCS Type: TWMethod: calibrated with polyalanine and drug standards]210.36 Å² [M+Na]+ [CCS Type: TW214.52 Å² [M+H]+ [CCS Type: TW214.45 Å² [M+K]+ [CCS Type: TW
밀도	1.72±0.1 g/cm3(Predicted)
저장 조건	-20°C Freezer
용해도	DMSO메타노에 용해됨
pKa(산도 계수)	0.82±0.60(Predicted)
물리적 상태	고체
색상	하얀색

안전 및 규제

기타 안전 정보	IMAP assessments - Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate: Environment tier I assessmentIMAP assessments - Adenosine, N-(1-oxobutyl)-, cyclic 3',5'-(hydrogen phosphate) 2'-butanoate: Human health tier I assessment
신호 어	Warning
유해·위험 문구	암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302

용도

개요

Bucladesine is a cyclic nucleotide derivative that mimics the action of endogenous CYCLIC AMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant. (From Merck Index, 11th ed)

용도

Bucladesine is a cell permeable cAMP analog. The compound is used in a wide variety of research applications because it mimics cAMP and can induce normal physiological responses when added to cells in experimental conditions. cAMP is only able to elicit minimal responses in these situations. The neurite outgrowth instigated by bucladesine in cell cultures has been shown to be enhanced by nardosinone.