기본 정보
- CAS
268729-12-0- 표준 SMILES
CC(C)(C)O[C@H]1C[C@H](C(=O)O)N(C(=O)OCC2c3ccccc3-c3ccccc32)C1- InChIKey
WPBXBYOKQUEIDW-YCRPNKLZSA-N- 분자식
- C24H27NO5
- 평균 분자량
- 409.5 g/mol
- 단동위원소 질량
- 409.18892296
이름 및 식별자
- 우선 이름
- Fmoc-O-tert-butyl-D-4-hydroxyproline
- IUPAC
- (2R,4S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxy]pyrrolidine-2-carboxylic acid
- 영어명
- FMoc-D-Hyp(tBu)-OH
- 분자식
- C24H27NO5
- 분자량
- 409.47
이름 및 동의어
268729-12-0FMOC-O-TERT-BUTYL-D-TRANS-4-HYDROXYPROLINEFmoc-D-Hyp(tBu)-OHFmoc-O-tert-butyl-D-4-hydroxyprolineMFCD11615628464193-92-8(2R,4S)-1-(9H-fluoren-9-ylmethoxycarbonyl)-4-[(2-methylpropan-2-yl)oxy]pyrrolidine-2-carboxylic acid(2R,4S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxy)pyrrolidine-2-carboxylic acidFmoc-trans-D-Hyp(tBu)-OHFmoc-o-t-Butyl-D-trans-4-hydroxyprolineSCHEMBL29397992SCHEMBL31437115
이름 더 보기
Icatibant Impurity 151-Fmoc-(4S)-4-tert-butoxy-D-prolineFmoc-O-tert-butyl-D-trans-4-hydroxyproline0.99(9H-Fluoren-9-yl)MethOxy]Carbonyl D-trans-Hyp(tBu)-OHN-α-(9-Fluorenylmethoxycarbonyl)-O-t-butyl-trans-4-hydroxy-D-proline(2R,4S)-1-(9-Fluorenylmethoxycarbonyl)-4-t-butoxypyrrolidine-2-carboxylic acid(2R,4S)-4-(tert-butoxy)-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}pyrrolidine-2-carboxylic acid
DTXSID10359657FF48573SY279623CS-0187839D83032F552665(4S)-4-tert-Butoxy-1-{[(9H-fluoren-9-yl)methoxy]carbonyl}-D-proline(2R,4S)-4-tert-butoxy-1-(9H-fluoren-9-ylmethoxycarbonyl)pyrrolidine-2-carboxylic acid
물성
구조 계산 물성
- XLogP
- 3.9
- 극성 표면적
- 76.1 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 5
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 30
- 형식 전하
- 0
- 복잡도
- 622
물리화학적 성질
- 끓는 점
- 578.6 · 578.6±50.0 °C(Predicted)
- 밀도
- 1.28 · 1.28±0.1 g/cm3(Predicted)
- 저장 조건
- 2 · 2-8°C
- 산도 계수 (pKa)
- 3.71 · 3.71±0.40(Predicted)
화학 및 산업
응용 분야
용도Fmoc-D-Hyp(tBu)-OH is used in the preparation of KMI-008 peptide derivatives and proline-based peptidomimetic analogs used as BACE1 inhibitors (β-secretase inhibitors).
공급사47 곳
江苏吉泰肽业科技有限公司18936337900 18936337900 · [email protected]
韶远科技(上海)有限公司4000665055 · [email protected]
江苏生康迈翔科技有限公司18217475093 · [email protected]
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
北京索莱宝科技有限公司010-50973130 17801761073 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
上海安化生物技术有限公司021-61263375 18168859245
上海相辉医药科技有限公司13761987713; 13761987713 · [email protected]
济南德迈医药科技有限公司18669728830 15806766175 · [email protected]
NANJING YINGWEN BIOTECHNOLOGY CO LTD+8613382787392 · [email protected]
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