기본 정보
- CAS
7460-12-0- 표준 SMILES
CN[C@@H](C)[C@@H](O)c1ccccc1.CN[C@@H](C)[C@@H](O)c1ccccc1.O=S(=O)(O)O- InChIKey
CAVQBDOACNULDN-NRCOEFLKSA-N- 분자식
- C20H32N2O6S
- 평균 분자량
- 428.5 g/mol
- 단동위원소 질량
- 428.19810792
개요
Pseudoephedrine Sulfate is the sulfate salt form of pseudoephedrine, a phenethylamine and a diastereomer of ephedrine with sympathomimetic property. Pseudoephedrine sulfate displaces norepinephrine from storage vesicles in presynaptic neurones, thereby releasing norepinephrine into the neuronal synapses where it stimulates primarily alpha-adrenergic receptors. It also has weak direct agonist activity at alpha- and beta- adrenergic receptors. Receptor stimulation results in vasoconstriction and decreases nasal and sinus congestion.
이름 및 식별자
- 우선 이름
- Pseudoephedrine Sulfate
- IUPAC
- bis((1S,2S)-2-(methylamino)-1-phenylpropan-1-ol);sulfuric acid
이름 및 동의어
Pseudoephedrine sulfate7460-12-0AfrinolSch 4855D-Isoephedrine sulfatepseudoephedrine sulphated-Pseudoephedrine sulfateY9DL7QPE6BSCH-4855(+)-pseudoephedrine sulfate(+)-PSEUDOEPHEDRINE SULPHATEDISOBROM COMPONENT PSEUDOEPHEDRINE SULFATE
이름 더 보기
DRIXORAL COMPONENT PSEUDOEPHEDRINE SULFATERESPORAL COMPONENT PSEUDOEPHEDRINE SULFATETRINALIN COMPONENT PSEUDOEPHEDRINE SULFATEDISOPHROL COMPONENT PSEUDOEPHEDRINE SULFATEBROMPHERIL COMPONENT PSEUDOEPHEDRINE SULFATECLARINEX-D COMPONENT PSEUDOEPHEDRINE SULFATECLARITIN-D COMPONENT PSEUDOEPHEDRINE SULFATEDRIXORAL PLUS COMPONENT PSEUDOEPHEDRINE SULFATE
데이터베이스 식별자
- CAS
7460-12-0- PubChem CID
- 9802673
- DTXSID
DTXSID20889379- ChEMBL
CHEMBL3989855- UNII
- Y9DL7QPE6B
- EC Number
- 231-243-2
물성
구조 계산 물성
- 극성 표면적
- 148 Ų
- 수소 결합 공여자 수
- 6
- 수소 결합 수용자 수
- 8
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 29
- 형식 전하
- 0
- 복잡도
- 202
실험 및 물리화학적 성질
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P260, P261, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 198 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Regulatory InformationREACH registered substance: Bis[[S-(R*,R*)]-(β-hydroxy-α-methylphenethyl)methylammonium] sulphate (EC: 231-243-2)
Other Safety InformationIMAP assessments - Benzenemethanol, .alpha.-[1-(methylamino)ethyl]-, [S-(R*,R*)]-, sulfate (2:1) (salt): Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
독성 정보
Exposure RoutesPseudoephedrine is readily and almost completely absorbed from the GI tract and there is no evidence of first-pass metabolism.
Toxicity Summary
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors.
화학 및 산업
약리 정보
Metabolism/MetabolitesHepatic.
Half Life: 9-16 hours
용도 및 제조
Uses
For the treatment of nasal congestion, sinus congestion, Eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism.
General Manufacturing InformationBenzenemethanol, .alpha.-[(1S)-1-(methylamino)ethyl]-, (.alpha.S)-, sulfate (2:1): ACTIVE
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