기본 정보
- CAS
136112-01-1- 표준 SMILES
CCC(=O)O[C@]1(C(=O)SCF)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C.OCc1cc(C(O)CNCCCCCCOCCCCc2ccccc2)ccc1O- InChIKey
YYAZJTUGSQOFHG-RZFXJYHSSA-N- 분자식
- C50H68F3NO9S
- 평균 분자량
- 916.1 g/mol
- 단동위원소 질량
- 915.45668841
이름 및 식별자
- 우선 이름
- Advair
- IUPAC
- [(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate;2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
- 영어명
- 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]phenol
- 분자식
- C50H68F3NO9S
- 분자량
- 0
이름 및 동의어
AdvairRefChem:915195viani136112-01-1Fluticasone/salmeterolSCHEMBL3989orb1679082TP2406Q581334Advair DiskusAdoairSeretide
이름 더 보기
Adoair DiskusFlutide DiskusSeretide AccuhalerSalMeterol-fluticasone propionate Mixt.SalMeterol Fluticasone Propionate Mixture[(6S,8S,10S,11S,13S,14S,16R)-6,9-difluoro-17-(fluoromethylsulfanylcarbonyl)-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate(6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-Methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid S-(FluoroMethyl) Ester Mixture with 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]aMino]Methyl]-1,3-benzenediMethanol
데이터베이스 식별자
- CAS
물성
구조 계산 물성
- 극성 표면적
- 188 Ų
- 수소 결합 공여자 수
- 5
- 수소 결합 수용자 수
- 14
- 회전 가능 결합 수
- 22
- 무거운 원자 수
- 64
- 형식 전하
- 0
- 복잡도
- 1,390
물리화학적 성질
- InChI
- InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2
- InChIKey
- GIIZNNXWQWCKIB-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(C(O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1CO
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
응용 분야
용도Salmeterol-fluticasone combination as Adoair, dry powder inhlaler/pressured metered-dose inhaler formulation for bronchial asthma, its benefit or demerits as device for inhalation drug delivery system in pharmacokinetics/pharmacodynamics at lung or peripheral bronchi, indications and usage of aerochamber, and clinical efficacy and safety in asthma control.
공급사5 곳
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北京百奥创新科技有限公司15522676233 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
深圳聚合生化科技有限公司+86-400-002-6226 13028896684 · [email protected]
北京百灵威科技有限公司18210857532 18210857532 · [email protected]
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