Zinc Hydroxide
20427-58-1[OH-].[OH-].[Zn+2]UGZADUVQMDAIAO-UHFFFAOYSA-LThe CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Hydroxide...
20427-58-1DTXSID7042516Liquid; Wet Solid
Colorless solid; [Hawley] White odorless powder; [MSDSonline]
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
This chemical does not meet GHS hazard criteria for 3.2% (11 of 348) of reports.
Warning
H315 (18.1%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P273, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, P362+P364, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 348 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Chemical: Zinc hydroxide (Zn(OH)2)
Zinc hydroxide (Zn(OH)2) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Zinc hydroxide (Zn(OH)2) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Zinc hydroxide (EC: 243-814-3)
Zinc hydroxide: Does not have an individual approval but may be used under an appropriate group standard
Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49)
CIR ingredient: Zinc Hydroxide
Used in chemical production, surgical dressings (absorbent), and rubber compounding; [Hawley]
Zinc hydroxide is used in surgical dressings. (L68)
Miscellaneous Manufacturing
Zinc hydroxide (Zn(OH)2): ACTIVE
용도Intermediate, absorbent in surgical dressings, rubber compounding.
The compound is prepared by adding a strong alkali to a solution of zinc sulfate or chloride: ZnSO4 + 2NaOH → Zn(OH)2 + Na2SO4.
불러오는 중…
Colorless crystals.Decomposes at 125C. Almost insoluble in water; forms both zinc salts and zincates.
6.1 [mg/m3]
67 [mg/m3]
400 [mg/m3]
The CIR Expert Panel concluded that the following 27 zinc salts are safe in cosmetics in the present practices of use and concentration described in this safety assessment when formulated to be non-irritating...Zinc Hydroxide...
Safe for use in cosmetics, with qualifications
Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)
Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49)