Edaglitazone

HCID 9825701

노트 반응

부분 구조 검색 유사 구조 찾기

기본 정보

CAS: 213411-83-7
표준 SMILES: Cc1oc(-c2ccccc2)nc1CCOc1ccc(CC2SC(=O)NC2=O)c2sccc12
InChIKey: HAAXAFNSRADSMK-UHFFFAOYSA-N
분자식: C24H20N2O4S2
평균 분자량: 464.6 g/mol
단동위원소 질량: 464.08644947

이름 및 식별자

우선 이름: Edaglitazone
IUPAC: 5-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]methyl]-1,3-thiazolidine-2,4-dione
영어명: 5-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzo[b]thiophen-7-yl)methyl)thiazolidine-2,4-dione
분자식: C24H20N2O4S2
분자량: 464.5566

이름 및 동의어

Edaglitazone213411-83-7Edaglitazona8GKF7V499BBM-131258R-4835-[[4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl]methyl]-1,3-thiazolidine-2,4-dioneDTXSID008702405-({4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}methyl)-1,3-thiazolidine-2,4-dioneedaglitazonum5-((4-(2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy)-1-benzothiophen-7-yl)methyl)-1,3-thiazolidine-2,4-dioneRefChem:590569

이름 더 보기

RO-2052349-602RO-2052349-0005-[[4-[2-(5-Methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-2,4-thiazolidinedione2,4-Thiazolidinedione, 5-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzo[b]thien-7-yl]methyl]-

DTXCID908180155-((4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzo[b]thiophen-7-yl)methyl)thiazolidine-2,4-dioneEdaglitazone [INN]Edaglitazone, (+)-Edaglitazone, (-)-QP6GWW0LZD59LQZ96XUUBM 131258

데이터베이스 식별자

CAS: 213411-83-7、892128-35-7、892128-36-8
PubChem CID: 9825701
DTXSID: DTXSID00870240
ChEMBL: CHEMBL3990804
UNII: 59LQZ96XUU、8GKF7V499B、QP6GWW0LZD
Nikkaji: J1.244.260B

물성

구조 계산 물성

XLogP: 5.5
극성 표면적: 135 Å²
수소 결합 공여자 수: 1
수소 결합 수용자 수: 7
회전 가능 결합 수: 7
무거운 원자 수: 32
형식 전하: 0
복잡도: 689

물리화학적 성질

밀도: 1.374 · 1.374
저장 조건: -20 °C · Store at -20°C
용해도: 30 mg/ml · DMSO: 30 mg/ml
물리적 상태: 결정성 고체
색상: White to off-white

화학 및 산업

응용 분야 · 2건

개요Edaglitazone is an agonist of peroxisome proliferator-activated receptor γ (PPARγ). It activates PPARγ in a reporter assay using CV-1 cells expressing murine PPARγ2 when used at concentrations ranging from 0.1 to 1 μM. Edaglitazone (1, 5, and 25 μM) increases [3H]2-deoxyglucose transport in the presence and absence of insulin and increases glycogen synthesis in the presence of insulin in soleus muscle strips isolated from obese rats.

용도Treatment of Type 2 diabetes.