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기본 정보
- CAS
272105-42-7- 표준 SMILES
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)[C@@H](C)O)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)CC- InChIKey
IUYPEUHIWDMJLM-INGCBPSVNA-N- 분자식
- C68H109N17O22S2
- 평균 분자량
- 1,580.84 g/mol
이름 및 식별자
- 우선 이름
- Disitertide
- 현지명
- 디시테타이드
- 영어명
- Disitertide
- 분자식
- C68H109N17O22S2
- 분자량
- 1580.84
이름 및 동의어
디시테타이드disitertideP144 PeptideTSLDASIIWAMMQNP144P144 PEPTIDEDISITERTIDE, >98%Disitertide,P144,P144 Peptide, >98%DisitertideH-Gly-Arg-Gly-Asp-Asn-Pro-OHL-Asparagine,L-threonyl-L-seryl-L-leucyl-L-a-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-Asparagine, L-threonyl-L-seryl-L-leucyl-L-α-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-Threonyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-seryl-L-isoleucyl-L-isoleucyl-L-tryptophyl-L-alanyl-L-methionyl-L-methionyl-L-glutaminyl-L-asparagine
데이터베이스 식별자
- CAS
272105-42-7- PubChem CID
- 9833838
물성
물리화학적 성질
- 끓는 점
- 1968.7 · 1968.7±65.0 °C(Predicted)
- 밀도
- 1.327 · 1.327
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- 200 mg/mL · DMSO : ≥ 200 mg/mL (126.52 mM);Water : < 0.1 mg/mL (insoluble)
- 산도 계수 (pKa)
- 3.15 · 3.15±0.10(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
- InChIKey
- IUYPEUHIWDMJLM-INGCBPSVNA-N
화학 및 산업
응용 분야
개요Disitertide is an inhibitor of TGF-β1. It prevents TGF-β1-dependent inhibition of MV1Lu proliferation in vitro and markedly reduces binding of TGF-β1 to its receptors. Disitertide blocks TGF-β1-dependent stimulation of a reporter gene under the control of human α2(I) collagen promoter. Treatment with Disitertide at low doses causes a significant inhibition of HSC activation and a marked reduction in liver fibrosis in a rat model of chronic exposure to CCl4. A dose as low as 70 μg of the 15-mer peptide Disitertide, given to rats (300 g body weight) on alternate days, decreases fibrogenesis significantly during chronic exposure to CCl4.
공급사48 곳
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中科华药(江苏)生物科技有限公司18020125070 · [email protected]
杭州思诺达医药科技有限责任公司0571-87213919 17306812703 · [email protected]
United Life Science020-82099279 18988968278 · [email protected]
InvivoChem中国13549236410 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
MedChemexpress LLC021-58955995 · [email protected]
Zhejiang J&C Biological Technology Co.,Limited+1-2135480471 · [email protected]
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