기본 정보
- CAS
3764-87-2- 표준 SMILES
C[C@@H]1CC2=CC(=O)CC[C@@H]2[C@H]2CC[C@]3(C)[C@@H](O)CC[C@H]3[C@@H]21- InChIKey
YSGQGNQWBLYHPE-CFUSNLFHSA-N- 분자식
- C19H28O2
- 평균 분자량
- 288.4 g/mol
- 단동위원소 질량
- 288.20893013
개요
Trestolone (7α-methyl-19-nortestosterone) is a synthetic androgen developed by the Population Council as a potential candidate drug for use in hormonal male contraceptive methods. In males, regular administration of sufficient quantities of trestolone induces a state of temporary infertility.
이름 및 식별자
- 우선 이름
- Trestolone
- IUPAC
- (7R,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
- 영어명
- Trestolone
- 분자식
- C19H28O2
- 분자량
- 288.42
이름 및 동의어
TrestoloneMENT3764-87-27alpha-Methyl-19-nortestosterone7alpha-Methylnandrolone19-Nor-methyltestosterone17beta-Hydroxy-7alpha-methylestr-4-en-3-one19-Nor-7alpha-methyltestosteroneMENTR7alpha-Methyl-3-oxo-4-estren-17beta-ol17beta-Hydroxy-7alpha-methylestr-4-enoneDTXSID20863270
이름 더 보기
Qulong7α-Methyl-19-NTSong holds dragonMythyl testosterone7α-Methylnandrolone7α-Methyl-19-nortestosterone19-nor-7a-methyltestosterone(7R)-17-Hydroxy-7,13-diMethyl-
7alpha-Methyl-17beta-hydroxy-4-estren-3-one17-hydroxy-7-methyl-4-estren-3-oneRU 2733340P3287I94HMEORU-27333MENT steroidNSC-142229
데이터베이스 식별자
- CAS
3764-87-2- PubChem CID
- 9838899
- DTXSID
DTXSID20863270
물성
구조 계산 물성
- XLogP
- 2.9
- 극성 표면적
- 37.3 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 2
- 회전 가능 결합 수
- 0
- 무거운 원자 수
- 21
- 형식 전하
- 0
- 복잡도
- 494
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
Endocrine DisruptorsPotential endocrine disrupting compound
물리화학적 성질
- 녹는점
- 145 · 145-146 °C
- 끓는 점
- 375.48 °C · 375.48°C (rough estimate)
- 밀도
- 0.9447 · 0.9447 (rough estimate)
- 굴절률
- 1.622 · 1.6220 (estimate)
- 저장 조건
- -20 °C · Store at -20°C
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 15.06 · 15.06±0.60(Predicted)
- 색상
- White to off-white
- 수용성
- 92 mg/L · 92mg/L(37℃)
- InChI
- InChI=1/C19H28O2/c1-11-9-12-10-13(20)3-4-14(12)15-7-8-19(2)16(18(11)15)5-6-17(19)21/h10-11,14-18,21H,3-9H2,1-2H3/t11-,14+,15-,16+,17+,18-,19+/s3
- InChIKey
- YSGQGNQWBLYHPE-IMRYQKHINA-N
- SMILES
- [C@@]12([H])[C@H](C)CC3=CC(=O)CC[C@]3([H])[C@@]1([H])CC[C@]1(C)[C@H](CC[C@@]21[H])O |&1:0,2,11,13,17,19,22,r|
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P203, P260, P263, P264, P270, P280, P301+P317, P318, P330, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 24 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 4 (100%)
안전 데이터
- 신호 어
- Danger
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H315
화학 및 산업
약리 정보
Mechanism of Action
Trestolone is a potent inhibitor of the release of the luteinizing hormone (LH) and follicle stimulating hormone (FSH). As spermatogenesis requires both testosterone and FSH, it is impaired by the reduction in FSH caused by trestolone as well as the reduction in LH, and subsequent reduction in testosterone.
MeSH Pharmacological ClassificationPostcoital contraceptives which owe their effectiveness to hormonal preparations.
응용 분야
개요Trestolone, also known as 7α-methyl-19-nortestosterone (MENT), is an experimental androgen/anabolic steroid (AAS) and progestogen medication which has been under development for potential use as a form of hormonal birth control for men and in androgen replacement therapy for low testosterone levels in men but has never been marketed for medical use.
용도Trestolone is a synthetic androgen used as a potential hormonal male contraceptive method that induces a state of termporary infertility.
상·하류 제품 정보
하류 제품
공급사39 곳
Shanghai Biolang Biotechnology Co., Ltd.+86-15970428662 +86-13397199602 · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]
Zhuzhou Yaozhijie Chemical Co., LTD+66-955486952 · [email protected]
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