기본 정보
- CAS
108560-70-9- 표준 SMILES
Cc1occc(=O)c1[O-].Cc1occc(=O)c1[O-].Cc1occc(=O)c1[O-].[Ga+3]- InChIKey
ASYYOZSDALANRF-UHFFFAOYSA-K- 분자식
- C18H15GaO9
- 평균 분자량
- 445 g/mol
- 단동위원소 질량
- 443.99718
개요
Gallium maltolate is Titan’s novel oral agent in development for the potential treatment of chronic bacterial infections, bone disease and cancer.
이름 및 식별자
- 우선 이름
- Gallium Maltolate
- IUPAC
- gallium tris(2-methyl-4-oxopyran-3-olate)
- 현지명
- GalliuM말톨레이트
- 영어명
- GalliuM Maltolate
- 분자식
- C18H15GaO9
- 분자량
- 445.03
이름 및 동의어
gallium maltolate108560-70-9tris(maltolato)gallium(III)17LEI49C2Gtris(3-hydroxy-2-methyl-4H-pyran-4-onato)gallium(III)4H-pyran-4-one, 3-hydroxy-2-methyl-, gallium salt (3:1)RefChem:142192DTXCID201527756DTXSID001045825gallium tris(2-methyl-4-oxo-4H-pyran-3-olate)gallium;2-methyl-4-oxopyran-3-olateC18H15GaO9
이름 더 보기
GalliuM말톨레이트GallixaGallium maltolate (Gallixa)GALLIUM MALTOLATE(108560-70-9)Gallium maltolate, 10 mM in DMSOTris[3-(hydroxy-κO)-2-Methyl-4H-pyran-4-onato-κO4]galliuMTris[3-(hydroxy-kappaO)-2-Methyl-4H-pyran-4-onato-kappaO4]galliuM
gallium;2-methyl-4-oxidanylidene-pyran-3-olate3-bis[(2-methyl-4-oxopyran-3-yl)oxy]gallanyloxy-2-methylpyran-4-oneGallium maltolate [WHO-DD]SCHEMBL29366290MFCD27976780DB05420DA-53477GALLIUM, TRIS(3-(HYDROXY-.KAPPA.O)-2-METHYL-4H-PYRAN-4-ONATO-.KAPPA.O4)-, (OC-6-21)-
데이터베이스 식별자
물성
구조 계산 물성
- 극성 표면적
- 148 Ų
- 수소 결합 공여자 수
- 0
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 0
- 무거운 원자 수
- 28
- 형식 전하
- 0
- 복잡도
- 200
물리화학적 성질
- 물리적 상태
- Solid
- 색상
- Off-white to light yellow
- 화장품 원료 기능
- 피부 컨디셔닝
- InChI
- InChI=1S/3C6H4O5.Ga/c3*7-3-1-2-11-5(4(3)8)6(9)10;/h3*1-2,8H,(H,9,10);/q;;;+3/p-3
- InChIKey
- LRPKBZSTANNRLK-UHFFFAOYSA-K
- SMILES
- [Ga+3].O1C(C([O-])=O)=C(O)C(=O)C=C1.O1C(C([O-])=O)=C(O)C(=O)C=C1.O1C(C([O-])=O)=C(O)C(=O)C=C1
화학 및 산업
약리 정보
Mechanism of Action
Gallium maltolate is a novel orally active formulation of gallium, a semi-metallic element that is a potent inhibitor of ribonucleotide reductase, an enzyme that promotes tumor growth.Gallium is also known to concentrate in malignant tumors and sites of infection, and appears to favorably impact calcium deposition, making bones more resistant to degradation caused by cancer metastasis. Titan's novel product, gallium maltolate, may significantly expand the therapeutic potential of gallium by providing the advantages of enhanced bioavailablity, a potentially improved therapeutic profile and ease of administration.
응용 분야
개요Gallium maltolate (GaM) is a new orally administered compound that has the potential to fundamentally improve the lives of many of these patients by providing effective treatment without serious side effects. GaM is being developed as an orally active formulation of gallium, a drug already approved by the FDA in intravenous form (gallium nitrate for injection). Clinical and preclinical studies have repeatedly shown gallium to have efficacy against cancer, inflammatory disorders, infectious disease, and bone loss.
공급사24 곳
合肥曼奇诺生物医药技术有限公司19719236623 · [email protected]
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
毕佳索（上海毕得医药科技股份有限公司）400-6005915 · [email protected]
北京颖诺凯胜科技有限公司010-56541685 13070143590 · [email protected]
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