기본 정보
- CAS
291533-11-4- 표준 SMILES
COc1ccc(C(=O)Nc2ccc(S(=O)(=O)NC(CC#CCN3CCOCC3)C(=O)O)cc2)cc1- InChIKey
JAYVKNDQKXUNOJ-UHFFFAOYSA-N- 분자식
- C24H27N3O7S
- 평균 분자량
- 501.6 g/mol
- 단동위원소 질량
- 501.15697138
개요
PG-530742 selectively inhibits certain matrix metalloproteinases that have been implicated in the cartilage degradation that occurs in osteoarthritis. By inhibiting these MMPs, it potentially limits cartilage degradation and disease progression. Studies are currently assessing the efficacy and safety of PG-530742 in the treatment of mild to moderate knee osteoarthritis.
이름 및 식별자
- 우선 이름
- PG-116800
- IUPAC
- 2-[[4-[(4-methoxybenzoyl)amino]phenyl]sulfonylamino]-6-morpholin-4-ylhex-4-ynoic acid
- 영어명
- PG 116800
- 분자식
- C24H27N3O7S
- 분자량
- 501.55208
이름 및 동의어
291533-11-4PG-116800F94T42GL80PG-5307424-Hexynoic acid, 2-(((4-((4-methoxybenzoyl)amino)phenyl)sulfonyl)amino)-6-(4-morpholinyl)-PGE7113313PGE-71133134-Hexynoic acid, 2-[[[4-[(4-methoxybenzoyl)amino]phenyl]sulfonyl]amino]-6-(4-morpholinyl)-RefChem:172346PG 116800PG-530742 free acidUNII-F94T42GL80
이름 더 보기
PG 116800,PG116800JAYVKNDQKXUNOJ-UHFFFAOYSA-N
PGE 530742PGE 7113313PG 5307422-[[4-[(4-methoxybenzoyl)amino]phenyl]sulfonylamino]-6-morpholin-4-ylhex-4-ynoic acidPG 530742; PGE 530742; PGE 7113313PG-116800 Sodium SaltPG-530742 SODIUMorb1699640
데이터베이스 식별자
- CAS
291533-11-4- PubChem CID
- 9848869
- ChEMBL
CHEMBL4297318- UNII
- F94T42GL80
물성
구조 계산 물성
- XLogP
- -0.8
- 극성 표면적
- 143 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 9
- 무거운 원자 수
- 35
- 형식 전하
- 0
- 복잡도
- 870
물리화학적 성질
- 물리적 상태
- Solid
- 색상
- White to off-white
화학 및 산업
약리 정보
Pharmacodynamics
PG-530742 selectively inhibits certain matrix metalloproteinases that have been implicated in the cartilage degradation that occurs in osteoarthritis. By inhibiting these MMPs, it potentially limits cartilage degradation and disease progression. Studies are currently assessing the efficacy and safety of PG-530742 in the treatment of mild to moderate knee osteoarthritis.
Mechanism of ActionPG-530742 selectively inhibits certain matrix metalloproteinases: In an independent research study, the drug-treated group showed decreased levels of MMP-2, -3, -9, and -13.
공급사5 곳
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
TargetMol中国（陶术生物）15002134094 · [email protected]
上海阿摩尔生物科技有限公司13370042665 18916960931 · [email protected]
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