기본 정보
- CAS
179474-85-2- 표준 SMILES
COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1.O=C(O)CCC(=O)O- InChIKey
QZRSNVSQLGRAID-UHFFFAOYSA-N- 분자식
- C22H32ClN3O7
- 평균 분자량
- 486 g/mol
- 단동위원소 질량
- 485.1928781
개요
Prucalopride Succinate is the succinate salt form of prucalopride, an orally bioavailable dihydro-benzofuran-carboxamide and selective serotonin (5-HT4) receptor agonist, with gastrointestinal (GI) prokinetic activity. Upon oral administration, prucalopride specifically targets, binds to and stimulates the 5-HT4 receptor. This alters colonic motility patterns and stimulates colonic mass movements. This may normalize bowel movements and may relief chronic constipation. In addition, by increasing esophageal and gastric motility, prucalopride may also provide relief for aspiration-associated symptoms.
이름 및 식별자
- 우선 이름
- Prucalopride Succinate
- IUPAC
- 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic acid
- 영어명
- Prucalopride Succinate
- 분자식
- C22H32ClN3O7
- 분자량
- 485.96
이름 및 동의어
Prucalopride succinate179474-85-2R-108512Prucalopride (as succinate)Motegrity4V2G75E1CKDTXSID701027749RefChem:57531DTXCID801513325ResolorPrucalopride SuccinatPrucalopride (succinate)
이름 더 보기
Resolor SuccinatePucapride SuccinatePRUCALOPRIDE SUCCITEPrucalopride ImpurityPriucapride succinatePulucapride Succinate
BUTANEDIOIC ACID 4-AMINO-5-CHLORO-2,3-DIHYDRO-N-[1-(3-METHOXYPROPYL)-4-PIPERIDINYL]-7-BENZOFURANCARBOXAMIDEMFCD00948731Prucalopride succinate [USAN]4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinateAKOS0159947414-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide;butanedioic acidKS-1283PRUCALOPRIDE SUCCINATE [ORANGE BOOK]
데이터베이스 식별자
- CAS
179474-85-2- PubChem CID
- 9870009
- DTXSID
DTXSID701027749- ChEMBL
CHEMBL2105748
물성
구조 계산 물성
- 극성 표면적
- 151 Ų
- 수소 결합 공여자 수
- 4
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 9
- 무거운 원자 수
- 33
- 형식 전하
- 0
- 복잡도
- 538
실험 및 물리화학적 성질
Human Drugs
Breastfeeding; Lactation; Gastrointestinal Agents; Laxatives; Serotonin 5-HT4 Receptor Agonists
FDA approved drugs -> Active ingredient
EMA approved medicines: Human medicine
FDA approved drugs -> Active ingredient
물리화학적 성질
- 녹는점
- 196 °C · >196°C (dec.)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 흰색에서 옅은 갈색까지
- InChIKey
- QZRSNVSQLGRAID-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCC(O)=O.O1C2=C(C(NC3CCN(CCCOC)CC3)=O)C=C(Cl)C(N)=C2CC1
화학적 성질
Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide is Off-White to Pale Brown Solid
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
GHS 분류
GHS Classification
Warning
H302 (87.5%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 8 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
유해성 정보
Hazard Classes and CategoriesAcute Tox. 4 (87.5%)
독성 정보
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Prucalopride succinate
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
안전 데이터
- 신호 어
- Warning
- 유해·위험 문구
- 암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드 H302
화학 및 산업
약리 정보
FDA Pharmacological Classification
PRUCALOPRIDE SUCCINATE
Serotonin 4 Receptor Agonists [MoA]; Serotonin-4 Receptor Agonist [EPC]
MeSH Pharmacological Classification
Agents that produce a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve CONSTIPATION.
Endogenous compounds and drugs that specifically stimulate SEROTONIN 5-HT4 RECEPTORS.
응용 분야
용도Prucalopride Succinate is the succinate form of prucalopride. It is a selective 5-HT4 receptor agonist used for the treatment of chronic constipation in adults for whom laxatives are not effective. It is not indicated for use in children and adolescents under 18 years of age.
공급사100 곳
济南百隆化学有限公司[email protected] · [email protected]
广州隽沐生物科技股份有限公司020-36607679; 13502246435 · [email protected]
湖北研科时代科技有限公司15780669880 · [email protected]
T&W GROUP021-61551611 13296011611 · [email protected]
Dayang Chem (Hangzhou) Co.,Ltd.+86-0571-88938639 17705817739 · [email protected]
芷威（上海）化学科技有限公司021-20221225 13917446399 · [email protected]
上海柯维化学技术有限公司021-64609169 18901607656 · [email protected]
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