기본 정보
- CAS
107188-66-9- 표준 SMILES
CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC- InChIKey
QAECXZXKVURFMR-LBPRGKRZSA-N- 분자식
- C16H23BrN2O3
- 평균 분자량
- 371.27 g/mol
- 단동위원소 질량
- 370.08921
개요
RN given refers to parent cpd without isomeric designation; structure given in first source
이름 및 식별자
- 우선 이름
- Flb 457
- IUPAC
- 5-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,3-dimethoxybenzamide
- 현지명
- (-)-(S)-5-BROMO-2,3-DIMETHOXY-N-[(1-ETHYL-2-PYR롤리디닐)메틸]-벤즈아미드
- 영어명
- (-)-(S)-5-Bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]-benzamide
- 분자식
- C16H23BrN2O3
- 분자량
- 371.27
이름 및 동의어
Flb 457Flb-457RefChem:140678107188-66-9107188-74-9Isoremoxipride5-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,3-dimethoxybenzamide(-)-(S)-5-Bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]-benzamideGH32HX9WCXCHEMBL289330(S)-5-BROMO-N-((1-ETHYLPYRROLIDIN-2-YL)METHYL)-2,3-DIMETHOXYBENZAMIDEBenzamide, 5-bromo-N-(((2S)-1-ethyl-2-pyrrolidinyl)methyl)-2,3-dimethoxy-
이름 더 보기
(-)-(S)-5-BROMO-2,3-DIMETHOXY-N-[(1-ETHYL-2-PYR롤리디닐)메틸]-벤즈아미드FLB 457107188-74-95-Bromo-2,3-dimethoxy-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]benzamideBENZAMIDE, 5-BROMO-N-[[(2S)-1-ETHYL-2-PYRROLIDINYL]METHYL]-2,3-DIMETHOXY-BENZAMIDE, 5-BROMO-2,3-DIMETHOXY-N-[(1-ETHYL-2-PYRROLIDINYL)METHYL]-, (S)-
5-BROMO-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-2,3-DIMETHOXYBENZAMIDEUNII-GH32HX9WCXorb3174725SCHEMBL5477770DTXSID40432689BDBM50007522AKOS0221801965-Bromo-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2,3-dimethoxy-benzamide
물성
구조 계산 물성
- XLogP
- 2.7
- 극성 표면적
- 50.8 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 22
- 형식 전하
- 0
- 복잡도
- 369
물리화학적 성질
- 녹는점
- 51 · 51-53°C
- 저장 조건
- -20 °C · -20°C Freezer
- 용해도
- 아세톤(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 색상
- 밝은 노란색에서 노란색까지
화학적 성질
Yellowish viscous oil
화학 및 산업
약리 정보
MeSH Pharmacological Classification
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
응용 분야
용도FLB 457 is an intermediate in the synthesis of FLB 457 Hydrobromide which is a potential antipsychotic agent; antidopaminergic.
공급사8 곳
奥夫仑医药（四川）有限公司17336178085 · [email protected]
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD+8613676922317 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
艾吉析科技（上海）有限公司17717235263 17717235263 · [email protected]
泰迩生物医药泰州有限公司052386810091 · [email protected]
江苏艾康生物医药研发有限公司025-58859352 17714375163 · [email protected]
济南睿思医药技术有限公司0531-0531-69900633 19963472814 · [email protected]
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