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기본 정보
- CAS
208518-52-9- 표준 SMILES
C/C(=C\c1csc(CO)n1)[C@@H]1C[C@@H]2O[C@]2(C)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1- InChIKey
UKIMCRYGLFQEOE-RGJAOAFDSA-N- 분자식
- C27H41NO7S
- 평균 분자량
- 523.7 g/mol
개요
Epothilone F is an epothilone.
이름 및 식별자
- 우선 이름
- Epothilone F
- IUPAC
- (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-3-[(E)-1-[2-(hydroxymethyl)-1,3-thiazol-4-yl]prop-1-en-2-yl]-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
- 현지명
- 에포틸론F
- 영어명
- epothilone F
- 분자식
- C27H41NO7S
- 분자량
- 523.68
이름 및 동의어
epothilone F208518-52-9GFX93BX7K3(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-3-[(E)-1-[2-(hydroxymethyl)-1,3-thiazol-4-yl]prop-1-en-2-yl]-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-3-((E)-1-(2-(hydroxymethyl)-1,3-thiazol-4-yl)prop-1-en-2-yl)-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dioneRefChem:137344(-)-Epothilone F(1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-3-((E)-1-(2-(hydroxymethyl)thiazol-4-yl)prop-1-en-2-yl)-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-3-((1E)-2-(2-(hydroxymethyl)-4-thiazolyl)-1-methylethenyl)-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo(14.1.0)heptadecane-5,9-dione4,17-Dioxabicyclo(14.1.0)heptadecane-5,9-dione, 7,11-dihydroxy-3-((1E)-2-(2-(hydroxymethyl)-4-thiazolyl)-1-methylethenyl)-8,8,10,12,16-pentamethyl-, (1S,3S,7S,10R,11S,12S,16R)-Epothilone F.UNII-GFX93BX7K3
이름 더 보기
에포틸론FCS-1032
물성
구조 계산 물성보충 중
- XLogP
- 2.9
- 극성 표면적
- 158 Ų
- 수소 결합 공여자 수
- 3
- 수소 결합 수용자 수
- 9
- 회전 가능 결합 수
- 3
- 무거운 원자 수
- 36
- 형식 전하
- 0
- 복잡도
- 833
물리화학적 성질
- 끓는 점
- 711.3 · 711.3±60.0 °C(Predicted)
- 밀도
- 1.179 · 1.179±0.06 g/cm3(Predicted)
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 13.15 · 13.15±0.10(Predicted)
- 색상
- Light yellow to yellow
화학 및 산업
응용 분야
용도Epothilone F is a related compound of Epothilones, which are a novel class of antineoplastic agents with antitubulin activity. In addition, Epothilones utilize a similar mechanism of action to that of taxanes and are less susceptible to multidrug resistance caused by P-glycoprotein. Studies showed that Epothilones exhibit antitumor activity against human cancer cells that are taxane-resistant.
공급사15 곳
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
天津尚德药缘科技有限公司13132578992 · [email protected]
Shanghai Witofly Chemical Co.,Ltd[email protected]
青岛海智微元生物科技有限公司18317699790 18317699790 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
Cckinase, Inc.+1 (732)236-3202 · [email protected]
湖北威德利化学科技有限公司027-83991130 18627774460 · [email protected]
上海临卡生物科技有限公司18301977208 · [email protected]
威尔曼医药集团有限公司15807197853 18971451745 · [email protected]
深圳聚合生化科技有限公司+86-400-002-6226 13028896684 · [email protected]
天津尚德药缘科技股份有限公司13370460931 · [email protected]
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