기본 정보
- CAS
481658-94-0- 표준 SMILES
CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(C(F)(F)F)cc3)ccc2n1C)c1ccccc1- InChIKey
TUOSYWCFRFNJBS-BHVANESWSA-N- 분자식
- C40H33F3N4O3
- 평균 분자량
- 674.7 g/mol
- 단동위원소 질량
- 674.25047558
개요
Dirlotapide is a drug employed in the treatment of obesity in dogs. It is marketed by Pfizer and Zoetis under the brand name, Slentrol, and is not intended for human use.
이름 및 식별자
- 우선 이름
- Dirlotapide
- IUPAC
- N-[(1S)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide
- 현지명
- 딜로타피드
- 영어명
- Dirlotapide
- 분자식
- C40H33F3N4O3
- 분자량
- 674.71
이름 및 동의어
Dirlotapide481658-94-0SlentroldirlotapidaCP-742033578H0RMP25CP-742,033DTXSID008974325-((4'-trifluoromethyl-biphenyl-2-carbonyl)-amino)-1H-indole-2-carboxylic acid benzylmethyl carbamoylamidedirlotapidumRefChem:58526DTXCID501326773
이름 더 보기
딜로타피드CP742033(S)-N-[2-[Benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[4'-(trifluoromethyl)-2-biphenylylcarboxamido]indole-2-carboxamide1H-Indole-2-carboxamide, 1-methyl-N-[(1S)-2-[methyl(phenylmethyl)amino]-2-oxo-1-phenylethyl]-5-[[[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]carbonyl]amino]-
N-((S)-(benzyl(methyl)carbamoyl)(phenyl)methyl)-1-methyl-5-(4'-(trifluoromethyl)-(1,1'-biphenyl)-2-amido)-1H-indole-2-carboximidic acidCHEMBL410414MFCD27976718N-[(1S)-2-[benzyl(methyl)amino]-2-oxo-1-phenylethyl]-1-methyl-5-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]indole-2-carboxamide1H-Indole-2-carboxamide, 1-methyl-N-((1S)-2-(methyl(phenylmethyl)amino)-2-oxo-1-phenylethyl)-5-(((4'-(trifluoromethyl)(1,1'-biphenyl)-2-yl)carbonyl)amino)-N-((1S)-2-(Benzylmethylamino)-2-oxo-1-phenylethyl)-1-methyl-5-(((4'-(trifluoromethyl)biphenyl-2-yl)carbonyl)amino)-1H-indole-2-carboxamideDirlotapide [USAN:INN]UNII-578H0RMP25
물성
구조 계산 물성
- XLogP
- 7.7
- 극성 표면적
- 83.4 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 6
- 회전 가능 결합 수
- 9
- 무거운 원자 수
- 50
- 형식 전하
- 0
- 복잡도
- 1,150
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Alimentary tract and metabolism -> Antiobesity preparations, excluding diet products
Animal DrugsActive Ingredients (Dirlotapide) -> FDA Greenbook
물리화학적 성질
- 끓는 점
- 821.2 · 821.2±65.0 °C(Predicted)
- 밀도
- 1.25 · 1.25±0.1 g/cm3(Predicted)
- 저장 조건
- -20 °C · Store at -20°C
- 용해도
- DMSO에 용해됨
- 물리적 상태
- Solid
- 산도 계수 (pKa)
- 12.4 · 12.40±0.46(Predicted)
- 색상
- White to off-white
화학 및 산업
약리 정보
ATC CodeQA - Alimentary tract and metabolism
용도 및 제조
Use ClassificationAnimal Drugs -> FDA Approved Animal Drug Products (Green Book) -> Active Ingredients
응용 분야
용도Treatment of obesity in companion animals (dogs) (gut microsomal triglyceride transport protein (gMTP) inhibitor) .
공급사15 곳
Aladdin Scientific[email protected]
MedChemexpress LLC021-58955995 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
韶远科技（上海）有限公司4000665055 · [email protected]
南通全益生物科技有限公司0513-66337626 18051384581 · [email protected]
上海芮晖化工科技有限公司021-31433387 15618786686 · [email protected]
武汉峰耀同辉化学制品有限公司027-87466105 15377573527 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
BOC Sciences
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