기본 정보
- CAS
211311-95-4- 표준 SMILES
CC(CNS(=O)(=O)C(C)C)c1ccc(-c2ccc(C#N)cc2)cc1- InChIKey
HOQAVGZLYRYHSO-UHFFFAOYSA-N- 분자식
- C19H22N2O2S
- 평균 분자량
- 342.5 g/mol
- 단동위원소 질량
- 342.14019912
이름 및 식별자
- 우선 이름
- N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamide
- IUPAC
- N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide
- 현지명
- N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드
- 영어명
- N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
- 분자식
- C19H22N2O2S
- 분자량
- 342.46
이름 및 동의어
211311-95-4N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonamideLY-404187LY404187LY 404187N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide75W6I8W6OUCHEMBL435582N-2-(4-(4-Cyanophenyl)phenyl)propyl 2-propanesulfonamide2-Propanesulfonamide, N-(2-(4'-cyano(1,1'-biphenyl)-4-yl)propyl)-N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamideLY-404,187
이름 더 보기
N-(2-(4'-시아노비페닐-4-일)프로필)프로판-2-설폰아미드100775CS-2739LY40418LY-404187, 10 mM in DMSON-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide
2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-N-(2-{4'-CYANO-[1,1'-BIPHENYL]-4-YL}PROPYL)PROPANE-2-SULFONAMIDEN-{2-[4-(4-cyanophenyl)phenyl]propyl}propane-2-sulfonamideMFCD07364003UNII-75W6I8W6OUGTPL4249orb1299575SCHEMBL2134262
데이터베이스 식별자
- CAS
물성
구조 계산 물성
- XLogP
- 3.8
- 극성 표면적
- 78.3 Ų
- 수소 결합 공여자 수
- 1
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 6
- 무거운 원자 수
- 24
- 형식 전하
- 0
- 복잡도
- 527
실험 및 물리화학적 성질
LogP3.5
물리화학적 성질
- 끓는 점
- 519 · 519.0±60.0 °C(Predicted)
- 밀도
- 1.19 · 1.19±0.1 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 15 mg/mL; · DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 11.24 · 11.24±0.40(Predicted)
- 색상
- White to off-white
화학 및 산업
응용 분야
개요LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.
용도LY 404187 is a novel positive allosteric modulator of AMPA receptors.
공급사40 곳
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
Aladdin Scientific[email protected]
上海波以尔化工有限公司[email protected]
InvivoChem中国13549236410 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
北京博奥森生物技术有限公司400-901-9800 18611424007 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
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