기본 정보
- CAS
5677-55-4- 표준 SMILES
COc1c(O)c(C)c(C/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CC/C=C(\C)CCC=C(C)C)c(O)c1OC- InChIKey
QNTNKSLOFHEFPK-UPTCCGCDSA-N- 분자식
- C59H92O4
- 평균 분자량
- 865.4 g/mol
- 단동위원소 질량
- 864.69956141
개요
Ubiquinol-10 is a ubiquinol in which the polyprenyl substituent is decaprenyl. It has a role as a metabolite and a biomarker. It is an ubiquinol and a polyprenylhydroquinone.
이름 및 식별자
- 우선 이름
- Ubiquinol
- IUPAC
- 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol
- 현지명
- 유비퀴놀
- 영어명
- Reduced Coenzyme Q10
- 분자식
- C59H92O4
- 분자량
- 865.36
이름 및 동의어
ubiquinolreduced coenzyme Q10Ubiquinone hydroquinoneM9NL0C577Y1,4-Benzenediol, 2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl]-5,6-dimethoxy-3-methyl-2-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaenyl]-5,6-dimethoxy-3-methylbenzene-1,4-diol1,4-Benzenediol, 2-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaen-1-yl)-5,6-dimethoxy-3-methyl-CHEBI:17976CoQH2reduced ubiquinoneRefChem:192853Ubiquinols
이름 더 보기
유비퀴놀Reduced Ubiquinone Q10CoQH2-10Ubiquinol 50Liposomal QHQ10UbiquinolWater Soluble Q10Ubiquinol solutionUbiquinol (1705334)
992-78-9Dihydrocoenzyme Q10ubiquinol-10Ubiquinol [WHO-DD]CoQ10H22-[(2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl]-5,6-dimethoxy-3-methylbenzene-1,4-diolMFCD119738162-((2E,6E,10E,14E,18E,22E,26E,30E,34E)-3,7,11,15,19,23,27,31,35,39-decamethyltetraconta-2,6,10,14,18,22,26,30,34,38-decaen-1-yl)-5,6-dimethoxy-3-methylbenzene-1,4-diol
물성
구조 계산 물성
- XLogP
- 20.2
- 극성 표면적
- 58.9 Ų
- 수소 결합 공여자 수
- 2
- 수소 결합 수용자 수
- 4
- 회전 가능 결합 수
- 31
- 무거운 원자 수
- 63
- 형식 전하
- 0
- 복잡도
- 1,600
실험 및 물리화학적 성질
DrugsPharmaceuticals -> Listed in ZINC15
CosmeticsCosmetic ingredients (Ubiquinol) -> CIR (Cosmetic Ingredient Review)
Physical DescriptionSolid
물리화학적 성질
- 녹는점
- 48 · 48-49°C
- 끓는 점
- 866.9 · 866.9±65.0 °C(Predicted)
- 밀도
- 0.951 · 0.951±0.06 g/cm3(Predicted)
- 저장 조건
- -20 °C · Amber Vial, -20°C Freezer, Under Inert Atmosphere
- 용해도
- 클로로포름: 용해성
- 물리적 상태
- 결정성 고체
- 산도 계수 (pKa)
- 10.53 · 10.53±0.50(Predicted)
- 주요 응용
- 의약품(소분자)
- InChIKey
- QNTNKSLOFHEFPK-UPTCCGCDSA-N
- SMILES
- C1(O)=C(OC)C(OC)=C(O)C(C)=C1C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(/C)\C
화학적 성질
안전 및 규제
안전 정보는 참고용이며, 공급업체의 물질안전보건자료(SDS), 관련 법규 및 전문가 평가를 대체하지 않습니다.
독성 정보
Toxicity SummarySafe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org
안전 데이터
- wgk
- WGK 3
- HS 번호
- 2909500000
- 스토리지 클래스
- 11 - Combustible Solids
화학 및 산업
약리 정보
Cellular LocationsExtracellular
용도 및 제조
UsesCIR ingredient: Ubiquinol
응용 분야
개요Ubiquinol is a reduced form of coenzyme Q10 (CoQ10; ), which exists in three redox states: fully oxidized (CoQ10/ubiquinone), partially reduced (semiquinone/ubisemiquinone), and fully reduced (ubiquinol). CoQ10 acts as an electron shuttle in the electron transport chain via its reduction to ubiquinol between mitochondrial complexes I and II, also known as NADH dehydrogenase and succinate dehydrogenase, respectively, and mitochondrial complex III, also known as cytochrome bc1 complex. CoQ10 is also reduced to ubiquinol by ferroptosis suppressor protein 1 (FSP1) with NADPH as a cofactor, and ubiquinol traps lipid peroxyl radicals and inhibits lipid peroxidation helping to prevent ferroptosis.
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