| GHS 분류 | This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1864) of reports.DangerH318 (14.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]P264+P265, P280, P305+P351+P338, P305+P354+P338, P317, and P337+P317 (click each P-code to see the statement)Aggregated GHS information provided per 1864 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.Warning |
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| 규제 정보 | Chemical: Benzeneacetic acidList I Chemical: A chemical specified by regulation that, in addition to legitimate uses, is used in manufacturing a controlled substance in violation of the Act and is important to the manufacture of a controlled substance. (21 eCFR 1310.02)Commission Regulation (EC) No 1565/2000 (Repealed by Com. Implementing Reg. (EU) No 872/2012)Benzeneacetic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Benzeneacetic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Status: Active Update: 13-05-2020 https://echa.europa.eu/registration-dossier/-/registered-dossier/11895Phenylacetic acid: Does not have an individual approval but may be used under an appropriate group standard |
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| 기타 안전 정보 | IMAP assessments - Benzeneacetic acid: Environment tier I assessment |
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| 화재 위험 | Combustible. |
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| 화재 가능성 | Combustible liquid |
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| 유해성 요약 | An eye and mild skin irritant[ICSC] A reproductive effector and moderate eye irritant[RTECS] Emergency medical treatment: irritants[HSDB] Safe when used as a flavoring agent in food[WHO JEFCA] An irritant[MSDSonline] |
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| FDA 요건 | Phenylacetic acid is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and 2) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.The following chemical has been specifically designated by the Administrator of the Drug Enforcement Administration as subject to the provisions of this part and parts 1309 and 1313 of this chapter. Phenylacetic acid, its esters and its salts are List 1 chemicalsDEA Code: 8791. |
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| Chemical Dangers | Decomposes on burning. This produces irritating fumes. The solution in water is a weak acid. Reacts with strong bases, strong oxidants and strong reducing agents. |
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| NFPA Hazard Classification | 2 - Materials that, under emergency conditions, can cause temporary incapacitation or residual injury.1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur.0 - Materials that in themselves are normally stable, even under fire conditions. |
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| Hazard Classes and Categories | Eye Dam. 1 (14.4%) |
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| Skin, Eye, and Respiratory Irritations | Inhalation: cough, sore throat. Skin: redness. Eyes: redness, pain |
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| Critical Temperature and Pressure | Critical temperature: 766 deg K, critical pressure: 3.9 MPa |
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| Hazardous Reactivities and Incompatibilities | Incompatible materials: Strong oxidizing agents, strong bases, strong reducing agents. |
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| 소화 | Use water spray, powder, foam, carbon dioxide. |
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| 응급 조치 | Fresh air, rest.Rinse skin with plenty of water or shower.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Give one or two glasses of water to drink. |
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| 안전 보관 | Separated from strong oxidants, strong bases and strong reducing agents. Store in an area without drain or sewer access. |
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| 소화 절차 | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.Powder, water spray, foam, carbon dioxide. |
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| 보관 조건 | Keep container tightly closed in a dry and well-ventilated place./Store/ separated from strong oxidants, strong bases and strong reducing agents. Store in an area without drain or sewer access. |
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| 정리 방법 | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures. Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.Do NOT let this chemical enter the environment. Sweep spilled substance into containers. |
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| 처리 방법 | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Contaminated packaging: Dispose of as unused product. |
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| 누출 처리 | Personal protection: filter respirator for organic gases and particulates adapted to the airborne concentration of the substance. Do NOT let this chemical enter the environment. Sweep spilled substance into covered containers. |
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| Preventive Measures | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures. Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Avoid breathing dust. Environmental precautions: Do not let product enter drains.Precautions for safe handling: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Further processing of solid materials may result in the formation of combustible dusts. The potential for combustible dust formation should be taken into consideration before additional processing occurs. Provide appropriate exhaust ventilation at places where dust is formed.Appropriate engineering controls: Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.For more Preventive Measures (Complete) data for Phenylacetic acid (6 total), please visit the HSDB record page. |
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| Eye Prevention | Wear safety goggles. |
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| Fire Prevention | NO open flames. |
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| Inhalation Risk | A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20 °C. |
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| 체내 부담 | Phenylacetic acid was present in 47.3% of the 54 samples of normal human expired air from an average concentration of 0.161 ng/L(1). Phenylacetic acid is detected in human faecal samples(2). Phenylacetic acid occurs as a protein-bound uremic compound in humans(3). |
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| Treatment | Kidney dialysis is usually needed to relieve the symptoms of uremic syndrome until normal kidney function can be restored. |
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| 건강 영향 | Chronic exposure to uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease. |
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| 생태독성 수치 | EC50Species: Xenopus laevis (African clawed frog) embryoConditions: freshwater, renewal, pH 7.0-7.8Concentration: 801900 ug/L for 96 hr (95% confidence interval: 761000-845000 ug/L)Effect: developmental changes (craniofacial defects, abnormal gut coiling) /> or = 98% purity/LC50Concentration: 1273700 ug/L for 96 hr (95% confidence interval: 1252000-1296000 ug/L) /> or = 98% purity/Species: Daphnia magna (Water flea)Conditions: freshwater, static, pH 8Concentration: 11 mg/L for 24 hrEffect: behavior, equilibrium |
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| 환경 거동 | TERRESTRIAL FATE: Based on a classification scheme(1), Koc values of 31, 26, and 28 from Podzol soil, Alfisol soil, and lake sediment, respectively(2) indicate that phenylacetic acid is expected to have very high mobility in soil(SRC). The pKa of phenylacetic acid is 4.31(3), indicating that this compound will exist almost entirely in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization from moist soil is not expected because the compound exists as an anion and anions do not volatilize. Phenylacetic acid is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure of 0.0038 mm Hg at 25 °C(5). Utilizing an unadapted soil suspension, biodegradation of 90% in 3 days was reported(6), indicating that biodegradation may be an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), Koc values of 31, 26 and 28, determined from Podzol soil, Alfisol soil, and lake sediment, respectively(2) indicate that phenylacetic acid is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 4.31(3) indicates phenylacetic acid will exist almost entirely in the anion form at pH values of 5 to 9(4) and, therefore, volatilization from water surfaces is not expected to be an important fate process. According to a classification scheme(5), an estimated BCF of 3(SRC), from a log Kow of 1.41(6) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Utilizing an unadapted soil suspension, biodegradation of 90% in 3 days was reported(8), suggesting that biodegradation may be an important environmental fate process in water(SRC). Under anaerobic conditions, phenylacetic acid biodegraded >90% in 60 days using municipal sewage waste water(9). Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions(4).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), phenylacetic acid, which has a vapor pressure of 3.8X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase phenylacetic acid is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3.6 days(SRC), calculated from its rate constant of 4.5X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Phenylacetic acid does not absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). |
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| 식품 조사 수치 | Phenylacetic acid was found as a volatile component in yellow box honey at 0.2 mg/kg and blue gum honey at 0.1 mg/kg(1). Phenylacetic acid was identified as a flavor compound in pine sprout tea and pine needle tea(2). Phenylacetic acid was detected in the volatiles of Rambutan fruit and in the juice at a concentration of 131.67 ug/L(3). Phenylacetic acid is reported to occur in guava, papaya, raspberry, strawberry, cooked potatoes, tomato, pepper, passion fruit, starfruit, mango, mushroom, rye bread, cheddar cheese, Swiss cheese, boiled mutton, beer, cognac, cider, sherry, grape wines, white wine, sake, cocoa, tea, honey soy protein, malt, and roasted chicory root(4). Reported food uses of phenylacetic acid include alcoholic beverages, baked goods, frozen dairy, gelatins, puddings and hard candy(4). |
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| 노출 경로 | Endogenous, Ingestion, Dermal (contact) |
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| 독성 요약 | IDENTIFICATION AND USE: Phenylacetic acid forms white to yellow crystals or flakes. It is used in perfume, as a precursor in manufacture of penicillin G, fungicide, flavoring, and laboratory reagent. It is also used in production of drugs of abuse. HUMAN STUDIES: Inhalation exposure leads to cough, sore throat. Skin exposure leads to redness. Eyes exposure leads to redness, pain. ANIMAL STUDIES: Acute oral toxicity in rats is low. In study of acute effects in mice, ip injection of 300 mg/kg was toxic. Phenylacetic acid did not promote tumor formation when given to rabbits iv and sc for 40 days. In vitro phenylacetic acid induced dose-related embryotoxicity above 0.3 mg/mL. In teratogenic study with rats, administration of 3.2 mg/kg phenylacetic acid on 12th day of embryogenesis affected body weight, retarded skeletal ossification, and caused embryos to be resorbed at twice rate of controls. Phenylacetic acid inhibits activity of coenzyme A.Uremic toxins such as phenylacetic acid are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate the production of reactive oxygen species. This seems to be mediated by the direct binding or inhibition by uremic toxins of the enzyme NADPH oxidase (especially NOX4 which is abundant in the kidneys and heart) (A7868). Reactive oxygen species can induce several different DNA methyltransferases (DNMTs) which are involved in the silencing of a protein known as KLOTHO. KLOTHO has been identified as having important roles in anti-aging, mineral metabolism, and vitamin D metabolism. A number of studies have indicated that KLOTHO mRNA and protein levels are reduced during acute or chronic kidney diseases in response to high local levels of reactive oxygen species (A7869) |
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| Average Daily Intake | The average Individual (food) intake of phenylacetic acid has been reported as 0.001002 mg/kg/day(1). |
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| 생태독성 발췌 | /OTHER TOXICITY INFORMATION/ In Pseudomonas aeruginosa, quorum sensing (QS) autoinducer known as acyl homoserine lactone (AHL) acts as a key regulator in the expression of pathogenic characters. In this work, the efficiency of phenylacetic acid (PAA) in reducing the production of AHL-dependent factors in P. aeruginosa PAO1 was studied. PAA at a concentration of 200 ug/mL displayed significant reduction in QS-dependent pyocyanin, exopolysaccharide, and protease and elastase production in PAO1. In swimming inhibition assay, PAA-treated PAO1 cells exhibited poor motility in swimming agar plate. In in vivo analysis, PAO1-preinfected Caenorhabditis elegans showed enhanced survival when treated with PAA. PAA at the QS inhibitory concentration showed no growth inhibitory activity on PAO1. Results of the present study revealed the potential of PAA as antipathogenic compound to prevent QS-dependent pathogenicity of P. aeruginosa. |
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| Plant Concentrations | Phenylacetic acid is reported to be a constituent in a few essential oils, tobacco, Bulgarian rose, and orange flowers. It is reportedly found in cocoa volatiles, guava, papaya, raspberry, strawberry, tomato, peppermint oil, pepper, passion fruit, starfruit, mango, and mushroom(1).Phenylacetic acid occurrence in plants(1).[Table#5010] |
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| Animal Concentrations | Ants from fungus farming colonies secrete and synthesize phenylacetic acid(1). |
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| 수질 위해 등급(WGK) | 3 |
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| 운송 번호(UN) | UN 2910 7 |
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| 위험 문구(R) | 36/37/38 |
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| 위험 표시 | Xi,R |
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| 안전 문구(S) | 26 |
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