HCID 18403070, 화합물 → HCID 9903422, 화합물

HRID 1003169노트

반응식

HRID 1003169 반응식
[CH2:1]([P:5]([CH2:8][CH:9]([C:22]([O:24]CC1C=CC=CC=1)=[O:23])[CH2:10][CH2:11][C:12]([O:14]CC1C=CC=CC=1)=[O:13])(=[O:7])[OH:6])[CH2:2][CH2:3][CH3:4]>O>[CH2:1]([P:5]([CH2:8][CH:9]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:22]([OH:24])=[O:23])([OH:7])=[O:6])[CH2:2][CH2:3][CH3:4]

참가 물질

3

반응물 1

HCID 18403070HCID 18403070, 화합물

생성물 1

HCID 9903422HCID 9903422, 화합물수율 43.3%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Butyl[2,4-di(benzyloxycarbonyl)butyl]phosphinic acid (2.9 g, 6.5 mmol) in 30 mL of water containing 0.32 g 10% Pd/C was hydrogenated on a Parr hydrogenator at 40 psi for 4.5 hours. The mixture was filtered through a pad of Celite and evaporated under high vacuum to give 2-[(butylhydroxyphosphinyl)methyl]pentanedioic acid (4, R=n-butyl) (0.75 g, 43%) as a clear and colorless viscous oil. 1H NMR (D2O): 2.4 ppm (m, 1H), 2.1 ppm (t, 2H), 1.9 ppm (m, 1H), 1.6 ppm (m, 3H), 1.4 ppm (m, 2H), 1.1 ppm (m, 4H), 0.6 ppm (t, 3H) Elemental Analysis Calculated C10H19O6P. 0.5 H2O: C 43.64, H 7.32: Found C 43.25, H 7.12

후처리

  1. filtrationThe mixture was filtered through a pad of Celite
  2. customevaporated under high vacuum

출처 및 근거

ORD 기록
ord-54eb03ef77d8497cb3eb9d78dc3a0dd6
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046180

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