HCID 18403062, 화합물 → HCID 178527042, 화합물
반응식
[CH2:1]([P:8](CC(C(OCC1C=CC=CC=1)=O)CCC(OCC1C=CC=CC=1)=O)(=[O:10])[OH:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O.[Pd]>[CH2:1]([PH:8](=[O:9])[OH:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1참가 물질
4
실험 절차
Benzyl[2,4-di(benzyloxycarbonyl)butyl]phosphinic acid(0.5 g, 1.0 mmol) in 20 mL of water containing 120 mg of 10% Pd/C was hydrogenated on a Parr hydrogenator at 40 psi for 6 hours. Filtration through a Celite pad followed by evaporation on high vacuum gave 0.17 g (57%) of 2-[(benzylhydroxyphosphinyl)methyl]pentanedioic acid(4,R=CH2Ph) as a white solid. 1H NMR (D2O): 7.1 ppm(m,5H), 2.9 ppm(d,2H), 2.4 ppm(m,1H), 2.1 ppm(t,2H), 1.8 ppm(m,1H), 1.6 ppm(m,3H) Elemental Analysis, Calculated C13H17O6P: C52.00H5.71: Found: C51.48H5.70
후처리
- filtrationFiltration through a Celite pad
- customfollowed by evaporation on high vacuum
- customgave 0.17 g (57%) of 2-[(benzylhydroxyphosphinyl)methyl]pentanedioic acid(4,R=CH2Ph) as a white solid
출처 및 근거
- ORD 기록
- ord-18de06b8c6684ab3be55b8b6adf7406d
- 출처 데이터셋
- uspto-grants-2000_04
- 특허 번호
- US06046180
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