Ethyl 4-(2-Aminopyrid-3-yloxy)butyrate → Ethyl 4-(2-(11-Carbomethoxyundecanoylamino)pyrid-3-yloxy)butyrate

반응식

[NH2:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:6][CH:5]=[CH:4][N:3]=1.[C:17]([O:32][CH3:33])(=[O:31])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]([O-])=[O:29]>>[C:17]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][C:28]([NH:1][C:2]1[C:7]([O:8][CH2:9][CH2:10][CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])=[CH:6][CH:5]=[CH:4][N:3]=1)=[O:29])([O:32][CH3:33])=[O:31]

참가 물질

반응물 2

HCID 18796228Ethyl 4-(2-Aminopyrid-3-yloxy)butyrate

HCID 22672980Dodecanedioic acid, monomethyl ester

생성물 1

HCID 19603103Ethyl 4-(2-(11-Carbomethoxyundecanoylamino)pyrid-3-yloxy)butyrate

실험 절차

When (41) and (7) are reacted as per the procedure of step (E), above, the title compound (42) is obtained. Hydrolysis will yield the corresponding di-acid (4-(2-(11- Carboxyundecanoylamino)pyrid-3-yloxy)butyric acid (43).

출처 및 근거

ORD 기록: ord-9935e6e5f83a44eb83fd04849ae79657
출처 데이터셋: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06046183

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