Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N-Dimethylaniline → 6-Benzylpyridin-2-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N-Dimethylaniline | HCID 949 | — |
| 반응물 | 2-(Phenylmethyl)pyridine | HCID 7581 | — |
| 반응물 | Sodium amide | HCID 24533 | — |
| 생성물 | 6-Benzylpyridin-2-amine | HCID 93902 | — |
반응 단계
2-benzylpyridine (Aldrich, 2.5 g, 0.015 mole), sodium amide (780 mg, 0.02 mole) and N,N-dimethylaniline (25 mL) were refluxed overnight. The contents were allowed to cool and were partitioned between ether and water. The ether layer was dried (MgSO4) and concentrated in vacuo leaving an oil. The oil was purified by chromatography. The purified material was dissolved in 1N HCl, lyophilized, and triturated with EtOAc to give 2-amino-6-benzylpyridine as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06046211 |
| 출처 데이터셋 | uspto-grants-2000_04 |
| ORD ID | ord-b4f6359734ba48bc95a711c609d6f9b5 |
| 출처 메모 | uspto-grants-2000_04 |