Triethylamine → 4-((1,3-Benzodioxol-5-ylmethyl)amino)-2,6-dichloro quinazoline
반응식
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:13])[CH:8]=2)[N:3]=1.[CH2:14]([NH2:24])[C:15]1[CH:23]=[CH:22][C:21]2[O:20][CH2:19][O:18][C:17]=2[CH:16]=1.C(N(CC)CC)C>C(O)(C)C>[Cl:1][C:2]1[N:11]=[C:10]([NH:24][CH2:14][C:15]2[CH:23]=[CH:22][C:21]3[O:20][CH2:19][O:18][C:17]=3[CH:16]=2)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:13])[CH:8]=2)[N:3]=1참가 물질
5
실험 절차
A mixture comprising 3.6 g of 2,4,6-trichloroquinazoline, 2.4 g of piperonylamine, 1.6 g of triethylamine and 50 ml of isopropyl alcohol was heated under reflux for 1.5 hours and hot-filtered to give 5.2 g of the title compound as a filter cake.
후처리
- temperaturewas heated
- temperatureunder reflux for 1.5 hours
- filtrationhot-filtered
출처 및 근거
- ORD 기록
- ord-74baae2f0a6841d1b167eedb42b84803
- 출처 데이터셋
- uspto-grants-2000_04
- 특허 번호
- US06046206
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