Trimethylsilyl iodide → HCID 18797398, 화합물

HRID 1003581노트

반응식

HRID 1003581 반응식
C1(C[O:5][C:6]2[CH:14]=[CH:13][CH:12]=[C:11]3[C:7]=2[C:8]([C:15]2[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH:20]=2)=[CH:9][NH:10]3)CC1.C[Si](I)(C)C>>[OH:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[C:8]([C:15]1[CH2:16][CH2:17][N:18]([CH3:21])[CH2:19][CH:20]=1)=[CH:9][NH:10]2

참가 물질

3

반응물 2

HCID 85247Trimethylsilyl iodideHCID 18797159HCID 18797159, 화합물

생성물 1

HCID 18797398HCID 18797398, 화합물수율 44%

실험 절차

Following the procedure described in detail in Example 58, 0.300 gm (1.1 mMol) 4-cyclopropylmethoxy-3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole were reacted with trimethylsilyl iodide to provide 0.11 gm (44%) of the title compound as a tan solid.

출처 및 근거

ORD 기록
ord-cb4b173e33f5498c83720b627de17d96
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046215

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