p-Toluenesulfonic acid → 2-Tetralone-6-carboxamide
반응식
C1O[C:4]2([CH2:13][CH2:12][C:11]3[C:6](=[CH:7][CH:8]=[C:9]([C:14]([NH2:16])=[O:15])[CH:10]=3)[CH2:5]2)[O:3]C1.C1(C)C=CC(S(O)(=O)=O)=CC=1>CC(C)=O>[CH2:5]1[C:6]2[C:11](=[CH:10][C:9]([C:14]([NH2:16])=[O:15])=[CH:8][CH:7]=2)[CH2:12][CH2:13][C:4]1=[O:3]참가 물질
4
실험 절차
2-Tetralone-6-carboxamide ethylene ketal (250 mg, 1.07 mmol) and catalytic p-toluenesulfonic acid were stirred in acetone (50 mL) at ambient temperature for 48 hours. The volatiles were removed in vacuo and the residue triturated in ethyl acetate. The solids were filtered, washed and dried to yield 77.5 mg (38%) of 2-Tetralone-6-carboxamide as a white powder, pure by NMR, TLC. MS.
후처리
- customThe volatiles were removed in vacuo
- customthe residue triturated in ethyl acetate
- filtrationThe solids were filtered
- washwashed
- customdried
출처 및 근거
- ORD 기록
- ord-f98270f4f7454820ac088ef9de76b3e8
- 출처 데이터셋
- uspto-grants-2000_04
- 특허 번호
- US06046227
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