Cyclohexyl methyl ketone → 3-(4-Benzyloxy-phenyl)-1-cyclohexyl-prop-2-en-1-one

HRID 1003807노트

반응식

HRID 1003807 반응식
[CH3:1][C:2]([CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[O:3].[CH2:10]([O:17][C:18]1[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[OH-].[Ba+2].[OH-]>CCO>[CH2:10]([O:17][C:18]1[CH:19]=[CH:20][C:21]([CH:22]=[CH:1][C:2]([CH:4]2[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]2)=[O:3])=[CH:24][CH:25]=1)[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

5

반응물 3

HCID 13207Cyclohexyl methyl ketoneHCID 78109Benzaldehyde, 4-(phenylmethoxy)-HCID 6093286Barium hydroxide

생성물 1

HCID 4714773-(4-Benzyloxy-phenyl)-1-cyclohexyl-prop-2-en-1-one

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

The title compound was prepared as described in General Method 2 using 17.40 g (138 mmol) of cyclohexyl methyl ketone, 29.26 g (138 mmol) of 4-benzyloxybenzaldehyde, 3.17 g of barium hydroxide (anhydrous), and 300 mL of 95% EtOH. The reaction was heated at reflux for eight hours. The crude product was recrystallized from EtOAc. The 25.85 g of product, contaminated with some 4-benzyloxybenzaldehyde, was taken on without further purification.

후처리

  1. temperatureThe reaction was heated
  2. temperatureat reflux for eight hours
  3. customThe crude product was recrystallized from EtOAc
  4. customwas taken on without further purification

출처 및 근거

ORD 기록
ord-62c3f2b409b7437bb8b2f41c43f136a0
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046355

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