Imidazole → 4-(4-tert-Butyldimethylsilyloxy-phenyl)-2-butanone

HRID 1003820

반응식

HRID 1003820 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10](=[O:12])[CH3:11])=[CH:4][CH:3]=1.[C:13]([Si:17](Cl)([CH3:19])[CH3:18])([CH3:16])([CH3:15])[CH3:14].N1C=CN=C1>CN(C=O)C>[Si:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10](=[O:12])[CH3:11])=[CH:6][CH:7]=1)([C:13]([CH3:16])([CH3:15])[CH3:14])([CH3:19])[CH3:18]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 216484-(4'-Hydroxyphenyl)-2-butanoneHCID 28928tert-Butyldimethylsilyl chloride

생성물 1

HCID 187986664-(4-tert-Butyldimethylsilyloxy-phenyl)-2-butanone

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The title compound was prepared as described in General Method 5 using 10 g (60.9 mmol) of 4-(4-hydroxyphenyl)-2-butanone, 10.1 g (67 mmol) of tert-butyldimethyl silyl chloride, 4.56 g (67 mmol) of imidazole and 150 mL of DMF. The crude product was carried on "as is" to the next step (see Example KK).

출처 및 근거

ORD 기록
ord-9e0343a3a4e04917aa1b04e4dbdc088b
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06046355

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