Sulfuric Acid → (R)-Methyl 2-(3-chlorophenyl)-2-hydroxyacetate

HRID 1004071노트

반응식

HRID 1004071 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]([OH:12])[C:9]([OH:11])=[O:10])[CH:5]=[CH:6][CH:7]=1.S(=O)(=O)(O)O.[C:18](=O)(O)[O-].[Na+]>CO>[CH3:18][O:10][C:9](=[O:11])[C@@H:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=1)[OH:12]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 516892Sodium BicarbonateHCID 2733127(R)-2-(3-Chlorophenyl)-2-hydroxyacetic acid

생성물 1

HCID 15606324(R)-Methyl 2-(3-chlorophenyl)-2-hydroxyacetate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of (R)-(3-chloro-phenyl)-hydroxy-acetic acid (19.98 g) in methanol (250 ml) containing concentrated sulphuric acid (1 ml) was heated under reflux for 6.5 h. The solution was cooled, neutralised with aqueous sodium bicarbonate solution, and concentrated. The residue was dissolved in ethyl acetate, washed with aqueous sodium bicarbonate solution, dried, and evaporated to give the title compound (21.13 g) as a pale-yellow oil.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 6.5 h
  3. temperatureThe solution was cooled
  4. concentrationconcentrated
  5. dissolutionThe residue was dissolved in ethyl acetate
  6. washwashed with aqueous sodium bicarbonate solution
  7. customdried
  8. customevaporated

출처 및 근거

ORD 기록
ord-507cf87ec1fc4f8188216dbaa001f800
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06048872

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