Dichloromethane → HCID 54440811, 화합물

HRID 1004290노트

반응식

HRID 1004290 반응식
O=[C:2]([CH3:11])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH:9]=[O:10].[C:12](C=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:14][CH2:15][CH3:16])=[O:13].[CH2:37](Cl)Cl>>[CH2:15]([O:14][C:12](=[O:13])[CH:11]=[CH:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][C:9](=[O:10])[CH3:37])[CH3:16]

참가 물질

4

반응물 3

HCID 6344Dichloromethane2회HCID 70670Acetic acid, 2-(triphenylphosphoranylidene)-, ethyl esterHCID 109316848-Oxo-nonanal

생성물 1

HCID 54440811HCID 54440811, 화합물

실험 절차

To a cooled (-40° C.) solution of 28-2 (10.8 g, 69.2 mmol) in 150 mL CH2Cl2 was added (carbethoxymethylene)triphenylphosphorane (24.1 g, 69.2 mmol) in 100 mL CH2Cl2 gradually over 15 min. The reaction mixture was stirred for 12 hr while it was warmed up to room temperature. After solvent removal, the residue was purified using silica gel flash chromatography (EtOAc/hexanes: 1:8 to 1:6) to afford the desired product 28-3 as an oil.

후처리

  1. customAfter solvent removal
  2. customthe residue was purified

출처 및 근거

ORD 기록
ord-f8a537f435da4956a71731e20d2eb2ea
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06048861

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