Methanol → Methyl [2-(trifluoromethyl)phenyl]acetate

HRID 1004308노트

반응식

HRID 1004308 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=[O:11].[CH3:15]O>S(=O)(=O)(O)O>[F:1][C:2]([F:13])([F:14])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([O:12][CH3:15])=[O:11]

참가 물질

4

반응물 2

HCID 887MethanolHCID 594597(2-(trifluoromethyl)phenyl)acetic acid

생성물 1

HCID 23294844Methyl [2-(trifluoromethyl)phenyl]acetate

시약·촉매·용매 1

HCID 1118Sulfuric Acid촉매

실험 절차

A solution of 2-trifluoromethylphenylacetic acid (5.0 g) in methanol (30 ml) containing 5 drops of concentrated sulphuric acid was heated at reflux for 2 hours. The reaction mixture was concentrated, diluted with ethyl acetate (100 ml), washed with 1N sodium hydroxide (25 ml) then with brine (25 ml), dried over magnesium sulphate and evaporated to give the title compound (5.04 g) as a colourless oil.

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 2 hours
  3. concentrationThe reaction mixture was concentrated
  4. additiondiluted with ethyl acetate (100 ml)
  5. washwashed with 1N sodium hydroxide (25 ml)
  6. dry with materialwith brine (25 ml), dried over magnesium sulphate
  7. customevaporated

출처 및 근거

ORD 기록
ord-e310ac7d8779480c96918d4b492204f8
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06048893

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