Benzyl Bromide → (3RS,4RS)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ol

HRID 1004942노트

반응식

HRID 1004942 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH:9]2[OH:14])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[CH2:21](Br)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(O)C>[CH2:21]([N:11]1[CH2:12][CH2:13][CH:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH:9]([OH:14])[CH2:10]1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 10340Sodium CarbonateHCID 221266524-(4-Fluorophenyl)piperidin-3-ol

생성물 1

HCID 22126857(3RS,4RS)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ol수율 74.2%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of 4.00 g (20.5 mmol) of (3RS,4RS)-4-(4-fluorophenyl)-piperidin-3-ol in 150 ml of ethanol was treated with 2.80 g (26.4 mmol) of sodium carbonate and refluxed. A solution of 2.50 ml (21.1 mmol) of benzyl bromide in 50 ml of ethanol was added dropwise within one hour and thereafter the mixture was held at reflux temperature for 2 hours. The pale brownish suspension was filtered and the filtrate was concentrated under reduced pressure. Subsequently, the residue was partitioned between methylene chloride and water, the organic phase was dried over magnesium sulphate and finally the solvent was distilled off under reduced pressure. The crude product was chromatographed on silica gel using a 2:3 mixture of ethyl acetate and hexane as the eluent. There were obtained 4.34 g (74% of theory) of (3RS,4RS)-1-benzyl-4-(4-fluoro-phenyl)-piperidin-3-ol as a colourless solid; MS: 285 (M)+.

후처리

  1. temperaturerefluxed
  2. temperatureat reflux temperature for 2 hours
  3. filtrationThe pale brownish suspension was filtered
  4. concentrationthe filtrate was concentrated under reduced pressure
  5. customSubsequently, the residue was partitioned between methylene chloride and water
  6. dry with materialthe organic phase was dried over magnesium sulphate
  7. distillationfinally the solvent was distilled off under reduced pressure
  8. customThe crude product was chromatographed on silica gel using
  9. additiona 2:3 mixture of ethyl acetate and hexane as the eluent

출처 및 근거

ORD 기록
ord-4275fdd12560453ba9814eadc4882da6
출처 데이터셋
uspto-grants-2000_04
특허 번호
US06051712

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