Borane → HCID 22127280, 화합물

반응식

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH:13]=2)=[CH:4][CH:3]=1.B.[O:16]1CCCC1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:9][CH2:10][N:11]([CH3:14])[CH2:12][CH:13]2[OH:16])=[CH:4][CH:3]=1

참가 물질

반응물 3

HCID 6331Borane

HCID 8028Tetrahydrofuran

HCID 787451-Methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine

생성물 1

HCID 22127280HCID 22127280, 화합물

실험 절차

In an analogous manner to that described in Example 1(c), from 4-(4-chloro-phenyl)-1-methyl-1,2,3,6-tetrahydropyridine [U.S. Pat. No. 3,320,265] by hydroboration using borane in tetrahydrofuran there was obtained (3RS,4RS)-4-(4-chloro-phenyl)-1-methyl-piperidin-3-ol which, after recrystallization from a mixture of methylene chloride and hexane, formed colourless crystals of m.p.: 99-100° C.

출처 및 근거

ORD 기록: ord-2faba196a32d427297e99e54c0eb0ea0
출처 데이터셋: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06051712

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