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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1004976생성일: 2026년 10월 26일

2-Chloromethyl-4-(beta-trimethylsilylethoxymethoxy)-naphthalene → tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-[4-(2-trimethylsilyl-ethoxy-methoxy)-naphthalen-2-ylmethoxy]-piperidine-1-carboxylate

https://huagongshe.com/reaction/1004976

반응식

참여 물질

역할이름HCID투입량
반응물2-Chloromethyl-4-(beta-trimethylsilylethoxymethoxy)-naphthaleneHCID 22126529—
반응물tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-hydroxy-piperidine-1-carboxylateHCID 54237291—
생성물tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-[4-(2-trimethylsilyl-ethoxy-methoxy)-naphthalen-2-ylmethoxy]-piperidine-1-carboxylateHCID 86604395—

반응 단계

In an analogous manner to that described in Example 1(g), by alkylating tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-hydroxy-piperidine-1-carboxylate with 2-chloromethyl-4-(β-trimethylsilyl-ethoxymethoxy)-naphthalene there was obtained tert-butyl (3RS,4RS)-4-(4-cyano-phenyl)-3-[4-(2-trimethylsilyl-ethoxy-methoxy)-naphthalen-2-ylmethoxy]-piperidine-1-carboxylate as a light yellow oil; MS: 530 [M-(C2H4 +CH2O)]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US06051712
출처 데이터셋uspto-grants-2000_04
ORD IDord-7c572eb96df844949ed27a8a2c0f397d
출처 메모uspto-grants-2000_04