2-Bromomethylnaphthalene → HCID 53996228, 화합물

반응식

[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([O:16][CH3:17])=[O:15])[CH:9]=2)[CH2:6][CH2:5][N:4]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:3]1.Br[CH2:26][C:27]1[CH:36]=[CH:35][C:34]2[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:28]=1>>[CH3:17][O:16][C:14]([C:10]1[CH:9]=[C:8]([CH:7]2[CH2:6][CH2:5][N:4]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:3][CH:2]2[O:1][CH2:26][C:27]2[CH:36]=[CH:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=2)[CH:13]=[CH:12][CH:11]=1)=[O:15]

참가 물질

반응물 2

HCID 703202-Bromomethylnaphthalene

HCID 53898470HCID 53898470, 화합물

생성물 1

HCID 53996228HCID 53996228, 화합물

실험 절차

In an analogous manner to that described in Example 22(i), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-(3-methoxycarbonyl-phenyl)-piperidine-1-carboxylate with 2-bromomethylnaphthalene there was obtained tert-butyl (3RS,4RS)-4-(3-methoxycarbonyl-phenyl)-3-naphthalen-2-ylmethoxy-piperidine-1-carboxylate as a colourless oil; MS: 493 (M+NH4)+.

출처 및 근거

ORD 기록: ord-332e96b5066e4016b2b50bc4595e24b4
출처 데이터셋: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06051712

반응 노트

불러오는 중…